Vestigial-like family member 3 explained

Vestigial-like family member 3 is a protein that in humans is encoded by the VGLL3 gene.^[1]

This protein is one of four mammalian homologs (VGLL1-4) of the vestigial gene found in the fruit fly Drosophila.^[2] VGLL3 functions as a transcription coregulator by binding to TEA domain (TEAD) transcription factors (TEAD1, TEAD2, TEAD3, TEAD4) through its TDU motif.^[3] VGLL3 has been implicated in various biological processes including myogenesis (formation of muscle tissue), cell proliferation, and cancer progression.^[4] VGLL3 can also promote epithelial-to-mesenchymal transition (EMT) and cell motility in certain cancer types, suggesting it may play a role in tumor development and metastasis.

See also

• Vestigial like family member 4

Further reading

• Tao S, Wang Z, Feng J, Hsu FC, Jin G, Kim ST, Zhang Z, Gronberg H, Zheng LS, Isaacs WB, Xu J, Sun J . A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants . Carcinogenesis . 33 . 3 . 598–603 . March 2012 . 22219177 . 3291863 . 10.1093/carcin/bgr316 .
• Gambaro K, Quinn MC, Wojnarowicz PM, Arcand SL, de Ladurantaye M, Barrès V, Ripeau JS, Killary AM, Davis EC, Lavoie J, Provencher DM, Mes-Masson AM, Chevrette M, Tonin PN . VGLL3 expression is associated with a tumor suppressor phenotype in epithelial ovarian cancer . Molecular Oncology . 7 . 3 . 513–30 . June 2013 . 23415753 . 10.1016/j.molonc.2012.12.006 . 5528482 .
• Zhou W, Chen H, Zhang L . The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor . BMB Reports . 42 . 3 . 154–9 . March 2009 . 19336002 . 10.5483/bmbrep.2009.42.3.154 . free .
• Halperin DS, Pan C, Lusis AJ, Tontonoz P . Vestigial-like 3 is an inhibitor of adipocyte differentiation . Journal of Lipid Research . 54 . 2 . 473–81 . February 2013 . 23152581 . 3541706 . 10.1194/jlr.M032755 . free .
• Hélias-Rodzewicz Z, Pérot G, Chibon F, Ferreira C, Lagarde P, Terrier P, Coindre JM, Aurias A . YAP1 and VGLL3, encoding two cofactors of TEAD transcription factors, are amplified and overexpressed in a subset of soft tissue sarcomas . Genes, Chromosomes & Cancer . 49 . 12 . 1161–71 . December 2010 . 20842732 . 10.1002/gcc.20825 . 205828045 .
• Wang L, Lu W, Chen YG, Zhou XM, Gu JR . Comparison of gene expression between normal colon mucosa and colon carcinoma by means of messenger RNA differential display . World Journal of Gastroenterology . 5 . 6 . 533–534 . December 1999 . 11819507 . 4688801 . 10.3748/wjg.v5.i6.533 . free .
• Maeda T, Chapman DL, Stewart AF . Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2 transcription factors that promotes skeletal muscle differentiation . The Journal of Biological Chemistry . 277 . 50 . 48889–98 . December 2002 . 12376544 . 10.1074/jbc.M206858200 . free .

Notes and References

1. Web site: Entrez Gene: Vestigial-like family member 3 .
2. Yamaguchi N . Multiple Roles of Vestigial-Like Family Members in Tumor Development . Frontiers in Oncology . 10 . 1266 . 2020 . 32793503 . 7393262 . 10.3389/fonc.2020.01266 . free .
3. Hori N, Takakura Y, Sugino A, Iwasawa S, Nomizo K, Yamaguchi N, Takano H, Yamaguchi N . Vestigial-like family member 3 stimulates cell motility by inducing high-mobility group AT-hook 2 expression in cancer cells . Journal of Cellular and Molecular Medicine . 26 . 9 . 2686–2697 . May 2022 . 35366053 . 9077286 . 10.1111/jcmm.17279 .
4. Hori N, Takakura Y, Sugino A, Iwasawa S, Nomizo K, Yamaguchi N, Takano H, Yamaguchi N . Vestigial-like family member 3 stimulates cell motility by inducing high-mobility group AT-hook 2 expression in cancer cells . Journal of Cellular and Molecular Medicine . 26 . 9 . 2686–2697 . May 2022 . 35366053 . 9077286 . 10.1111/jcmm.17279 .