Prunetin Explained

Prunetin is an O-methylated isoflavone, a type of flavonoid. It has been isolated for the first time by Finnemore in 1910 in the bark of Prunus emarginata (the Oregon cherry).^[1] Prunetin isolated from pea roots can act as an attractant for Aphanomyces euteiches zoospores.^[2] It is also an allosteric inhibitor of human liver aldehyde dehydrogenase.^[3]

Prunetin can lower blood pressure of spontaneously hypertensive rats and relax isolated rat aortic rings through calcium channel block mechanisms in vessel smooth muscles.^[4]

Glycosides

• 8-C-glucosyl prunetin, isolated from the leaves of Dalbergia hainanensis^[5]

See also

• List of phytochemicals in food
• Biochanin A

Notes and References

1. 10.1021/jo01180a006 . 10 . 4 . 1945 . The Journal of Organic Chemistry . 288–291 . Shriner . R. L. . Hull . Clarence J.. Isoflavones. III. The Structure of Prunetin and a New Synthesis of Genistein1 .
2. Yokosawa . Ryozo . Kuninaga . Shiro . Sekizaki . Harua . 1986 . Aphanomyces euteiches zoospore attractant isolated from pea root; prunetin . Ann. Phytopath. Soc. Japan . 52 . 5. 809–816 . 10.3186/jjphytopath.52.809 . free .
3. Sheikh . S. . Weiner . H. . 1997 . Allosteric inhibition of human liver aldehyde dehydrogenase by the isoflavone prunetin . . 53 . 4. 471–478 . 10.1016/s0006-2952(96)00837-4. 9105397 .
4. 10.3390/molecules23092372 . free . 6225200 . 30227625 . Prunetin Relaxed Isolated Rat Aortic Rings by Blocking Calcium Channels . 2018 . Kim . Bumjung . Jo . Cheolmin . Choi . Ho-Young . Lee . Kyungjin . Molecules . 23 . 9 . 2372 .
5. Conformational Study of 8-C-glucosyl-prunetin by Dynamic NMR Spectroscopy . Pei Cheng Zhang, Ying Hong Wang, Xin Liu, Xiang Yi, Ruo Yun Chen and De Quan Yu . Chinese Chemical Letters . 13 . 7 . 645–648 . 2002 .