Phosphatidate cytidylyltransferase explained

Phosphatidate cytidylyltransferase ^{[1] [2] [3]} (also known as CDP- diacylglycerol synthase) (CDS) is the enzyme that catalyzes the synthesis of CDP-diacylglycerol from cytidine triphosphate and phosphatidate.

CTP + phosphatidate

diphosphate + CDP-diacylglycerol

Thus, the two substrates of this enzyme are cytidine triphosphate, or CTP, and phosphatidate, whereas its two products are diphosphate and CDP-diacylglycerol.

CDP-diacylglycerol is an important branch point intermediate in both prokaryotic and eukaryotic organisms. CDS is a membrane-bound enzyme.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is . Other names in common use include , , , , , , , , , and CDP-DG. This enzyme participates in glycerophospholipid metabolism and phosphatidylinositol signaling system.

References

• Carter JR, Kennedy EP . 1966 . Enzymatic synthesis of cytidine diphosphate diglyceride . Journal of Lipid Research . 7 . 678 - 83 . 4291255 . 5 . 10.1016/S0022-2275(20)39250-6 . free .
• McCaman RE, Finnerty WR . 1968 . Biosynthesis of cytidine diphosphate-diglyceride by a particulate fracgion from Micrococcus cerificans . Journal of Biological Chemistry . 243 . 5074 - 80 . 5679981 . 19 . 10.1016/S0021-9258(18)91993-9 . free .
• Petzold GL, Agranoff BW . 1967 . The biosynthesis of cytidine diphosphate diglyceride by embryonic chick brain . Journal of Biological Chemistry . 242 . 1187 - 91 . 6067194 . 6 . 10.1016/S0021-9258(18)96162-4 . free .

Notes and References

1. Sparrow CP, Raetz CR . Purification and properties of the membrane-bound CDP-diglyceride synthetase from Escherichia coli . Journal of Biological Chemistry . 260 . 22 . 12084–12091 . 1985 . 10.1016/S0021-9258(17)38989-5 . 2995359. free .
2. Shen H, Heacock PN, Clancey CJ, Dowhan W . The CDS1 gene encoding CDP-diacylglycerol synthase in Saccharomyces cerevisiae is essential for cell growth . Journal of Biological Chemistry . 271 . 2 . 789–795 . 1996 . 8557688 . 10.1074/jbc.271.2.789. free .
3. Kondo H, Goto K, Saito S, Tonosaki A . Gene cloning and characterization of CDP-diacylglycerol synthase from rat brain . Journal of Biological Chemistry . 272 . 14 . 9503–9509 . 1997 . 9083091 . 10.1074/jbc.272.14.9503. free .