Opticin Explained

Opticin is a protein that in humans is encoded by the OPTC gene.^{[1] [2]}

Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are typically associated with the extracellular matrix. Opticin is present in significant quantities in the vitreous of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver. Opticin may noncovalently bind collagen fibrils and regulate fibril morphology, spacing, and organization. The opticin gene is mapped to a region of chromosome 1 that is associated with the inherited eye diseases age-related macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa (AXPC1).

Further reading

• Hobby P, Wyatt MK, Gan W, etal . Cloning, modeling, and chromosomal localization for a small leucine-rich repeat proteoglycan (SLRP) family member expressed in human eye. . Mol. Vis. . 6 . 72–8 . 2000 . 10837509 .
• Friedman JS, Ducharme R, Raymond V, Walter MA . Isolation of a novel iris-specific and leucine-rich repeat protein (oculoglycan) using differential selection. . Invest. Ophthalmol. Vis. Sci. . 41 . 8 . 2059–66 . 2000 . 10892843 .
• Armerding D, Fuhlbrigge RC, Kieffer JD, Kupper TS . Tonsillar B cells do not express PSGL-1, but a significant fraction displays the cutaneous lymphocyte antigen and exhibits effective E- and P-selectin ligand activity. . Int. Arch. Allergy Immunol. . 126 . 1 . 78–90 . 2001 . 11641609 . 10.1159/000049497 . 45610233 .
• Friedman JS, Faucher M, Hiscott P, etal . Protein localization in the human eye and genetic screen of opticin. . Hum. Mol. Genet. . 11 . 11 . 1333–42 . 2002 . 12019215 . 10.1093/hmg/11.11.1333 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Le Goff MM, Hindson VJ, Jowitt TA, etal . Characterization of opticin and evidence of stable dimerization in solution. . J. Biol. Chem. . 278 . 46 . 45280–7 . 2003 . 12951322 . 10.1074/jbc.M303117200 . free .
• Ramesh S, Bonshek RE, Bishop PN . Immunolocalisation of opticin in the human eye. . The British Journal of Ophthalmology . 88 . 5 . 697–702 . 2004 . 15090426 . 10.1136/bjo.2003.031989 . 1772128 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Liu T, Qian WJ, Gritsenko MA, etal . Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. . J. Proteome Res. . 4 . 6 . 2070–80 . 2006 . 16335952 . 10.1021/pr0502065 . 1850943 .
• Acharya M, Mookherjee S, Bhattacharjee A, etal . Evaluation of the OPTC gene in primary open angle glaucoma: functional significance of a silent change. . BMC Mol. Biol. . 8. 21 . 2007 . 17359525 . 10.1186/1471-2199-8-21 . 1838427 . free .

Notes and References

1. Reardon AJ, Le Goff M, Briggs MD, McLeod D, Sheehan JK, Thornton DJ, Bishop PN . Identification in vitreous and molecular cloning of opticin, a novel member of the family of leucine-rich repeat proteins of the extracellular matrix . J Biol Chem . 275 . 3 . 2123–9 . Feb 2000 . 10636917 . 10.1074/jbc.275.3.2123 . free .
2. Web site: Entrez Gene: OPTC opticin.