Mir-24 microRNA precursor family explained

The miR-24 microRNA precursor is a small non-coding RNA molecule that regulates gene expression. microRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a mature ~22 nucleotide product. In this case the mature sequence comes from the 3' arm of the precursor. The mature products are thought to have regulatory roles through complementarity to mRNA. miR-24 is conserved in various species, and is clustered with miR-23 and miR-27, on human chromosome 9 and 19.^[1] Recently, miR-24 has been shown to suppress expression of two crucial cell cycle control genes, E2F2 and Myc in hematopoietic differentiation ^[2] and also to promote keratinocyte differentiation by repressing actin-cytoskeleton regulators PAK4, Tsk5 and ArhGAP19.

Targets of miR-24

• Lal et al. suggested that miR-24 suppresses the tumor suppressor p16(INK4a).^[1]
• Lal et al. reported that mi-24 inhibits cell proliferation by targeting E2F2, MYC via binding to "seedless" 3'UTR microRNA recognition elements.^[2]
• Amelio I. et al. suggest that miR-24 regulates keratinocyte differentiation, controlling actin-cytoskeleton dynamics via PAK4, Tsk5 and ArhGAP19 repression.^[3]
• Wang et al. have shown that miR-24 reduces the mRNA and protein levels of human ALK4 by targeting the 3'-untranslated region of mRNA.^[4]
• Mishra et al. suggest that miR-24 targets the DHFR gene.^[5]
• miR-24-1, also known as miR-189, targets SLITRK1.^{[6] [7]}

External links

• • miRBase family MIPF0000041

Notes and References

1. Lal A, Kim HH, Abdelmohsen K, etal . Preiss . Thomas . p16(INK4a) translation suppressed by miR-24 . PLOS ONE . 3 . 3 . e1864 . 2008 . 18365017 . 2274865 . 10.1371/journal.pone.0001864 . 2008PLoSO...3.1864L . free .
2. Lal A, Navarro F, Maher CA, Maliszewski LE, Yan N, O'Day E, Chowdhury D, Dykxhoorn DM, Tsai P, Hofmann O, Becker KG, Gorospe M, Hide W, Lieberman J. Preiss . Thomas . miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements. . Molecular Cell . 35 . 5 . 610–25 . 2009 . 19748357 . 10.1016/j.molcel.2009.08.020 . 2757794.
3. Amelio I, Lena AM, Viticchiè G, Shalom-Feuerstein R, Terrinoni A, Dinsdale D, Russo G, Fortunato C, Bonanno E, Spagnoli LG, Aberdam D, Knight RA, Candi E, Melino G . miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration . The Journal of Cell Biology . 199 . 2 . October 2012 . 23071155 . 10.1083/jcb.201203134 . 347–63. 3471232 .
4. Wang Q, Huang Z, Xue H, etal . MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4 . Blood . 111 . 2 . 588–95 . January 2008 . 17906079 . 10.1182/blood-2007-05-092718 . free .
5. Mishra PJ, Humeniuk R, Mishra PJ, Longo-Sorbello GS, Banerjee D, Bertino JR . A miR-24 microRNA binding-site polymorphism in dihydrofolate reductase gene leads to methotrexate resistance . Proceedings of the National Academy of Sciences of the United States of America . 104 . 33 . 13513–8 . August 2007 . 17686970 . 1948927 . 10.1073/pnas.0706217104 . 2007PNAS..10413513M . free .
6. Abelson . J. F. . Benthe . HF . Haberland . G . Sequence Variants in SLITRK1 Are Associated with Tourette's Syndrome . Science . 14 October 2005 . 310 . 5746 . 317–320 . 10.1126/science.1116502. 16224024 . 2005Sci...310..317A . 30102870 .
7. Larsen . K . Momeni . J . Farajzadeh . L . Bendixen . C . Porcine SLITRK1: Molecular cloning and characterization. . FEBS Open Bio . 2014 . 4 . 872–8 . 10.1016/j.fob.2014.10.001 . 25379384. 4215120 .