Leiomodin 1 Explained

Leiomodin 1 is a protein that in humans is encoded by the LMOD1 gene.^[1]

Function

The leiomodin 1 protein has a putative membrane-spanning region and 2 types of tandemly repeated blocks. The transcript is expressed in all tissues tested, with the highest levels in thyroid, eye muscle, skeletal muscle, and ovary. Increased expression of leiomodin 1 may be linked to Graves' disease and thyroid-associated ophthalmopathy. [provided by RefSeq, Jul 2008].

Further reading

• Conley CA, Fowler VM . Localization of the human 64kD autoantigen D1 to myofibrils in a subset of extraocular muscle fibers . Curr. Eye Res. . 19 . 4 . 313–22 . October 1999 . 10.1076/ceyr.19.4.313.5304 . 10520227 .
• Conley CA, Fritz-Six KL, Almenar-Queralt A, Fowler VM . Leiomodins: larger members of the tropomodulin (Tmod) gene family . Genomics . 73 . 2 . 127–39 . April 2001 . 11318603 . 10.1006/geno.2000.6501 .
• Conley CA . Leiomodin and tropomodulin in smooth muscle . Am. J. Physiol., Cell Physiol. . 280 . 6 . C1645–56 . June 2001 . 11350761 . 10.1152/ajpcell.2001.280.6.C1645 . 20779719 . free .
• Lane HY, Liu YC, Huang CL, Chang YC, Wu PL, Lu CT, Chang WH . Risperidone-related weight gain: genetic and nongenetic predictors . J Clin Psychopharmacol . 26 . 2 . 128–34 . April 2006 . 16633140 . 10.1097/01.jcp.0000203196.65710.2b . 34821033 .
• Hosgood HD, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q . Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway . Carcinogenesis . 29 . 10 . 1938–43 . October 2008 . 18676680 . 2722857 . 10.1093/carcin/bgn178 .
• Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q . Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China . Environ. Mol. Mutagen. . 50 . 4 . 285–90 . May 2009 . 19170196 . 2666781 . 10.1002/em.20452 . 2009EnvMM..50..285S .
• Hosgood HD, Menashe I, He X, Chanock S, Lan Q . PTEN identified as important risk factor of chronic obstructive pulmonary disease . Respir Med . 103 . 12 . 1866–70 . December 2009 . 19625176 . 2783799 . 10.1016/j.rmed.2009.06.016 .
• Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N . Genetic susceptibility to distinct bladder cancer subphenotypes . Eur. Urol. . 57 . 2 . 283–92 . February 2010 . 19692168 . 3220186 . 10.1016/j.eururo.2009.08.001 .
• Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD . Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip . Am. J. Hum. Genet. . 85 . 5 . 628–42 . November 2009 . 19913121 . 2775832 . 10.1016/j.ajhg.2009.10.014 .

Notes and References

1. Web site: Entrez Gene: Leiomodin 1. 2018-03-12.