Haplogroup Q-M120 Explained

Q-M120
Origin-Date:15 400 ybp
Origin-Place:Asia or South Siberia
Ancestor:Q1a1a (F746/NWT01)
Mutations:M120 and M265 (AKA N14)

Haplogroup Q-M120, also known as Q1a1a1, is a Y-DNA haplogroup. It is the only primary branch of haplogroup Q1a1a (F746/NWT01). The lineage is most common amongst modern populations in eastern Eurasia.

But the haplogroup might have been historically widespread in the Eurasian steppe and north Asia since it is found among Cimmerians in Moldova and Bronze Age natives of Khövsgöl.[1]

Distribution

The Americas

One of the 1K Genomes samples, HG01944, from Peruvians in Lima, Peru belongs to Q-M120. Q-M120 is the other branch under Q-F746. It is best known as an East Asian branch of Q. This is intriguing; if it is not a result of post-colonial admixture, it will mark a fourth or fifth Q lineage in the Americas. The branch of Q-M120 including this sample has a calculated TMRCA of 5,000 to 7,000 years, meaning that it may be the result of a later pre-Columbian immigration from North or East Asia.

Grugni et al. (2019) found the presence of the Q-pre-M120 lineage, a precursor to Q-M120, among the Tsimshian people in Alaska.

Asia

Q-M120 is present in Eastern Asia and may trace its origin to East Asia.[2] [3] It has been found at low frequency in samples of Han Chinese,[4] Dungans, Hmong Daw in Laos,[5] Japanese,[6] Dörwöd Kalmyks,[7] Koreans,[8] Mongols,[9] [10] Tibetans,[11] [12] Uygurs,[13] and Vietnamese.[14] [15] It also has been found among Bhutanese,[16] Murut people in Brunei,[17] Tuvans,[18] Nivkhs,[19] Koryaks,[19] Yukaghirs,[19] and Azerbaijanis. Sengupta et al. (2006) reported finding Q-M120 in the HGDP sample of Pakistani Hazaras,[20] but the Bayesian tree in Supplementary Figure 12 of Lippold et al. (2014) suggests that these HGDP Pakistani Hazara individuals more likely should belong to Q-L275, and that three members of the HGDP Naxi sample and one member of the HGDP Han sample should belong to Q-M120 instead.[21] Di Cristofaro et al. (2013) tested the same sample of Pakistani Hazaras and reported that they belonged to the following Y-DNA haplogroups: 1/25 C-PK2/M386(xM407, M532), 9/25 C-M401, 1/25 I-M223, 1/25 J-M530, 2/25 O-M122(xM134), 1/25 Q-M242(xM120, M25, M346, M378), 1/25 Q-M378, 1/25 R-M124, 8/25 R-M478/M73.

PopulationPaperNPercentageSNP Tested
Nivkh (Sakhalin)Kharkov 20243/37~8.1%M120
Dungan (Kyrgyzstan)Wells 20013/40~7.5%M120
Han (Henan)Su 20002/28~7.1%M120
KoryakKharkov 20241/20~5.0%M120
Han (Anhui)Su 20001/22~4.6%M120
Northern HanSu 20001/22~4.5%M120
Kinh
(Ho Chi Minh City)		Poznik 20162/46~4.3%M120
Tuvan (Kungurtug)Luis 20231/24~4.17%M120
Evenk (Yakutia)Kharkov 20241/28~3.5%M120
Han (Shanghai)Su 20001/30~3.3%M120
Han (Shandong)Su 20001/32~3.1%M120
KoreaWells 20011/45~2.2%M120
Tibetan (Lhasa)Su 20001/46~2.2%M120
TibetGayden 20072/156~1.3%M120
Han (Shanxi)Zhong 20101/56~1.8%M120
Uygur (Xinjiang)Zhong 20101/71~1.4%M120
Uygur (Xinjiang)Zhong 20101/50~2.0%M120
Hmong Daw (Laos)Cai 20111/51~1.96%M120
Han (Jiangsu)Su 20001/55~1.8%M120
Di Cristofaro 20132/160~1.25%M120
Dörwöd KalmykMalyarchuk 20134/426~0.9%M120
Nonaka 20071/263~0.38%M120

According to a 2019 study, Q-M120 can be found in high concentrations in the northern and eastern regions of China. To a lesser extent, it can be found in North Korea, South Korea and northern Philippines.[22]

South Asia

Sharma et al. (2007) found Q-M120 in 1.6% (1/61) of a sample of Gujars from Jammu and Kashmir in India.[23]

West Asia

Q-M120 has been found in 4.2% (1/24) of Baloch people in Sistan and Baluchestan Province.[24]

Europe

Caucasus

Q-M120 was found in western Georgia among Imeretians.[25]

Associated SNPs

Haplogroup Q-M120 is defined by the presence of the M120 Single Nucleotide Polymorphism (SNP) as well as the M265 (AKA N14) SNP.

Phylogenetic tree

This is Thomas Krahn at the Genomic Research Center's Draft Tree for haplogroup Q-M120.

See also

Y-DNA backbone tree

External links

Notes and References

  1. Sun . Na . Ma . Peng-Cheng . Yan . Shi . Wen . Shao-Qing . 3 . 2019 . Phylogeography of Y-chromosome haplogroup Q1a1a-M120, a paternal lineage connecting populations in Siberia and East Asia . Annals of Human Biology . 46 . 3 . 261–266 . 10.1080/03014460.2019.1632930 . 31208219 . Taylor & Francis Online.
  2. Grugni . Viola . Raveane . Alessandro . Ongaro . Linda . Battaglia . Vincenza . Trombetta . Beniamino . Colombo . Giulia . Capodiferro . Marco Rosario . Olivieri . Anna . Achilli . Alessandro . Perego . Ugo A. . Motta . Jorge . Tribaldos . Maribel . Woodward . Scott R. . Ferretti . Luca . Cruciani . Fulvio . 2019 . Analysis of the human Y-chromosome haplogroup Q characterizes ancient population movements in Eurasia and the Americas . BMC Biology . 17 . 1 . 3 . 10.1186/s12915-018-0622-4 . 1741-7007 . 6345020 . 30674303 . free .
  3. 10.1007/s004390000406 . Y chromosome haplotypes reveal prehistorical migrations to the Himalayas . 2000 . Su . Bing . Xiao . Chunjie . Deka . Ranjan . Seielstad . Mark T. . Kangwanpong . Daoroong . Xiao . Junhua . Lu . Daru . Underhill . Peter . Cavalli-Sforza . Luca . Human Genetics . 107 . 6 . 582–90 . 11153912 . 36788262 .
  4. Wen B . Genetic evidence supports demic diffusion of Han culture . Nature . 431 . 7006 . 302–5 . September 2004 . 15372031 . 10.1038/nature02878 . Li H . Lu D . 2004Natur.431..302W . 4301581 . etal . – Supplementary Table 2: NRY haplogroup distribution in Han populations
  5. Cai X, Qin Z, Wen B, Xu S, Wang Y, et al. (2011), "Human Migration through Bottlenecks from Southeast Asia into East Asia during Last Glacial Maximum Revealed by Y Chromosomes." PLoS ONE 6(8): e24282. doi:10.1371/journal.pone.0024282
  6. 10.1111/j.1469-1809.2006.00343.x . Y-chromosomal Binary Haplogroups in the Japanese Population and their Relationship to 16 Y-STR Polymorphisms . 2007 . Nonaka . I. . Minaguchi . K. . Takezaki . N. . Annals of Human Genetics . 71 . 4 . 480–95 . 17274803. 10130/491 . 1041367 . free .
  7. Boris Malyarchuk, Miroslava Derenko, Galina Denisova, Sanj Khoyt, Marcin Woźniak, Tomasz Grzybowski, and Ilya Zakharov, "Y-chromosome diversity in the Kalmyks at the ethnical and tribal levels." Journal of Human Genetics (2013) 58, 804–811; doi:10.1038/jhg.2013.108
  8. Wells RS . The Eurasian Heartland: A continental perspective on Y-chromosome diversity . Proc. Natl. Acad. Sci. U.S.A. . 98 . 18 . 10244–9 . August 2001 . 11526236 . 56946 . 10.1073/pnas.171305098 . Yuldasheva N . Ruzibakiev R . 2001PNAS...9810244W . etal . free . – Table 1: Y-chromosome haplotype frequencies in 49 Eurasian populations, listed according to geographic region
  9. Battaglia V, Grugni V, Perego UA, Angerhofer N, Gomez-Palmieri JE, et al. (2013), "The First Peopling of South America: New Evidence from Y-Chromosome Haplogroup Q." PLoS ONE 8(8): e71390. doi:10.1371/journal.pone.0071390
  10. Di Cristofaro J, Pennarun E, Mazières S, Myres NM, Lin AA, et al. (2013) "Afghan Hindu Kush: Where Eurasian Sub-Continent Gene Flows Converge." PLoS ONE 8(10): e76748. doi:10.1371/journal.pone.0076748
  11. Gayden T . The Himalayas as a Directional Barrier to Gene Flow . Am. J. Hum. Genet. . 80 . 5 . 884–94 . May 2007 . 17436243 . 1852741 . 10.1086/516757 . Cadenas AM . Regueiro M . etal .
  12. Wang C-C, Wang L-X, Shrestha R, Zhang M, Huang X-Y, et al. (2014), "Genetic Structure of Qiangic Populations Residing in the Western Sichuan Corridor." PLoS ONE 9(8): e103772. doi:10.1371/journal.pone.0103772
  13. 10.1093/molbev/msq247 . Extended Y Chromosome Investigation Suggests Postglacial Migrations of Modern Humans into East Asia via the Northern Route . 2010 . Zhong . H. . Shi . H. . Qi . X.-B. . Duan . Z.-Y. . Tan . P.-P. . Jin . L. . Su . B. . Ma . R. Z. . Molecular Biology and Evolution . 28 . 717–27 . 20837606 . 1. free .
  14. https://www.yfull.com/tree/Q/ YFull Haplogroup YTree
  15. G. David Poznik, Yali Xue, Fernando L. Mendez, et al. (2016), "Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences." Nature Genetics 2016 June ; 48(6): 593–599. doi:10.1038/ng.3559.
  16. Pille Hallast, Chiara Batini, Daniel Zadik, et al., "The Y-chromosome tree bursts into leaf: 13,000 high-confidence SNPs covering the majority of known clades." Molecular Biology and Evolution Advance Access publication December 2, 2014. doi:10.1093/molbev/msu327
  17. Monika Karmin, Lauri Saag, Mário Vicente, et al. (2015), "A recent bottleneck of Y chromosome diversity coincides with a global change in culture." Genome Research 25:1–8. Published by Cold Spring Harbor Laboratory Press; ISSN 1088-9051/15; www.genome.org.
  18. Luis . Javier Rodriguez . Palencia-Madrid . Leire . Garcia-Bertrand . Ralph . Herrera . Rene J. . 2023-01-23 . Bidirectional dispersals during the peopling of the North American Arctic . Scientific Reports . en . 13 . 1 . 1268 . 10.1038/s41598-023-28384-8 . 2045-2322 . 9871004 . 36690673. 2023NatSR..13.1268L .
  19. Kharkov . V. N. . Kolesnikov . N. A. . Valikhova . L. V. . Zarubin . A. A. . Sukhomyasova . A. L. . Khitrinskaya . I. Yu. . Stepanov . V. A. . 2024-10-09 . Traces of Paleolithic expansion in the Nivkh gene pool based on data on autosomal SNP and Y chromosome polymorphism . Vavilov Journal of Genetics and Breeding . 28 . 6 . 659–666 . 10.18699/vjgb-24-73 . 2500-3259 . 11496309 . 39445096.
  20. 10.1086/499411 . Polarity and Temporality of High-Resolution Y-Chromosome Distributions in India Identify Both Indigenous and Exogenous Expansions and Reveal Minor Genetic Influence of Central Asian Pastoralists . 2006 . Sengupta . Sanghamitra . Zhivotovsky . Lev A. . King . Roy . Mehdi . S.Q. . Edmonds . Christopher A. . Chow . Cheryl-Emiliane T. . Lin . Alice A. . Mitra . Mitashree . Sil . Samir K. . The American Journal of Human Genetics . 78 . 2 . 202–21 . 16400607 . 1380230 .
  21. Sebastian Lippold, Hongyang Xu, Albert Ko, Mingkun Li, Gabriel Renaud, Anne Butthof, Roland Schröder, and Mark Stoneking, "Human paternal and maternal demographic histories: insights from high-resolution Y chromosome and mtDNA sequences." Investigative Genetics 2014, 5:13. http://www.investigativegenetics.com/content/5/1/13
  22. Sun . Na . Ma . Peng-Cheng . Yan . Shi . Wen . Shao-Qing . 3 . 2019 . Phylogeography of Y-chromosome haplogroup Q1a1a-M120, a paternal lineage connecting populations in Siberia and East Asia . Annals of Human Biology . 46 . 3 . 261–266 . 10.1080/03014460.2019.1632930 . 31208219 . Taylor & Francis Online.
  23. Sharma . Swarkar . Rai . Ekta . Bhat . Audesh K. . Bhanwer . Amarjit S. . Bamezai . Rameshwar NK . 2007-11-19 . A novel subgroup Q5 of human Y-chromosomal haplogroup Q in India . BMC Evolutionary Biology . 7 . 1 . 232 . 10.1186/1471-2148-7-232 . free . 1471-2148 . 2258157 . 18021436. 2007BMCEE...7..232S .
  24. Grugni . Viola . Battaglia . Vincenza . Kashani . Baharak Hooshiar . Parolo . Silvia . Al-Zahery . Nadia . Achilli . Alessandro . Olivieri . Anna . Gandini . Francesca . Houshmand . Massoud . Sanati . Mohammad Hossein . Torroni . Antonio . Semino . Ornella . 2012-07-18 . Ancient Migratory Events in the Middle East: New Clues from the Y-Chromosome Variation of Modern Iranians . PLOS ONE . en . 7 . 7 . e41252 . 10.1371/journal.pone.0041252 . free . 1932-6203 . 3399854 . 22815981. 2012PLoSO...741252G .
  25. Alborova . I.E. . Pocheshkhova . E.A. . Chikovani . N.L. . Dibirova . K.D. . 1 . October 2016 . FEATURES OF THE GENE POOL LAZ AND IMERETIANSS ACCORDING ABOUT Y-CHROMOSOME POLYMORPHISMS . Modern Problems of Science and Education . 315.

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