Gougerotin Explained

Gougerotin is a water-soluble pyrimidine-based antibiotic which is produced by the bacteria Streptomyces graminearus and Streptomyces gougerotii.^{[1] [2] [3] [4]} Gougerotin is named after the dermatologist Henri-Eugène Gougerot.^[2] Gougerotin has activity against Gram-positive and Gram-negative bacteria as well as against viruses.^[2]

Further reading

• Clark JM, Gunther JK . Gougerotin, a specific inhibitor of protein synthesis . Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects . 76 . 636–8 . December 1963 . 14099625 . 10.1016/0926-6550(63)90092-6 .
• Burkett AR, Schlender KK, Sell HM . Gougerotin—an inhibitor of protein synthesis and auxin-induced elongation in plants . Phytochemistry . March 1970 . 9 . 3 . 545–547 . 10.1016/S0031-9422(00)85687-3. 1970PChem...9..545B .
• Book: Gottlieb D, Shaw PD . Mechanism of Action . 6 December 2012 . Springer Science & Business Media . 978-3-642-46051-7 . 281 . en.
• Barbacid M, Vazquez D . (G-3H)gougerotin binding to ribosomes. Heterogeneity of eukaryotic ribosomes . European Journal of Biochemistry . 44 . 2 . 445–53 . May 1974 . 4600364 . 10.1111/j.1432-1033.1974.tb03502.x . free .

Notes and References

1. Book: Yukioka M . Gougerotin . Mechanism of Action of Antimicrobial and Antitumor Agents . 1975 . 448–458 . 10.1007/978-3-642-46304-4_29. 978-3-642-46306-8 .
2. Gougerotin . www.spektrum.de . de.
3. Book: Comprehensive Natural Products III . 22 July 2020 . Elsevier . 978-0-08-102691-5 . 528 . en.
4. Gougerotin . www.spektrum.de . de.