Gem-associated protein 2 explained

Gem-associated protein 2 (GEMIN2), also called survival of motor neuron protein-interacting protein 1 (SIP1), is a protein that in humans is encoded by the GEMIN2 gene.^{[1] [2] [3]}

Interactions

Gem-associated protein 2 has been shown to interact with DDX20^{[4] [5]} and SMN1.^{[2] [6]}

See also

• Gideon Dreyfuss
• Spinal muscular atrophy

Further reading

• Wang Z, Wu X, Friedberg EC . Molecular mechanism of base excision repair of uracil-containing DNA in yeast cell-free extracts . The Journal of Biological Chemistry . 272 . 38 . 24064–24071 . September 1997 . 9295360 . 10.1074/jbc.272.38.24064 . free .
• Zhang WJ, Wu JY . Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing . Molecular and Cellular Biology . 18 . 2 . 676–684 . February 1998 . 9447963 . 108778 . 10.1128/mcb.18.2.676 .
• Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G . Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems . The Journal of Cell Biology . 147 . 6 . 1181–1194 . December 1999 . 10601333 . 2168095 . 10.1083/jcb.147.6.1181 .
• Charroux B, Pellizzoni L, Perkinson RA, Yong J, Shevchenko A, Mann M, Dreyfuss G . Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli . The Journal of Cell Biology . 148 . 6 . 1177–1186 . March 2000 . 10725331 . 2174312 . 10.1083/jcb.148.6.1177 .
• Helmken C, Wetter A, Rudnik-Schöneborn S, Liehr T, Zerres K, Wirth B . An essential SMN interacting protein (SIP1) is not involved in the phenotypic variability of spinal muscular atrophy (SMA) . European Journal of Human Genetics . 8 . 7 . 493–499 . July 2000 . 10909848 . 10.1038/sj.ejhg.5200479 . free .
• Meister G, Bühler D, Laggerbauer B, Zobawa M, Lottspeich F, Fischer U . Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins . Human Molecular Genetics . 9 . 13 . 1977–1986 . August 2000 . 10942426 . 10.1093/hmg/9.13.1977 . free .
• Young PJ, Man NT, Lorson CL, Le TT, Androphy EJ, Burghes AH, Morris GE . The exon 2b region of the spinal muscular atrophy protein, SMN, is involved in self-association and SIP1 binding . Human Molecular Genetics . 9 . 19 . 2869–2877 . November 2000 . 11092763 . 10.1093/hmg/9.19.2869 . free .
• Selenko P, Sprangers R, Stier G, Bühler D, Fischer U, Sattler M . SMN tudor domain structure and its interaction with the Sm proteins . Nature Structural Biology . 8 . 1 . 27–31 . January 2001 . 11135666 . 10.1038/83014 . 27071310 .
• Pellizzoni L, Charroux B, Rappsilber J, Mann M, Dreyfuss G . A functional interaction between the survival motor neuron complex and RNA polymerase II . The Journal of Cell Biology . 152 . 1 . 75–85 . January 2001 . 11149922 . 2193649 . 10.1083/jcb.152.1.75 .
• Jablonka S, Bandilla M, Wiese S, Bühler D, Wirth B, Sendtner M, Fischer U . Co-regulation of survival of motor neuron (SMN) protein and its interactor SIP1 during development and in spinal muscular atrophy . Human Molecular Genetics . 10 . 5 . 497–505 . March 2001 . 11181573 . 10.1093/hmg/10.5.497 . free .
• Friesen WJ, Massenet S, Paushkin S, Wyce A, Dreyfuss G . SMN, the product of the spinal muscular atrophy gene, binds preferentially to dimethylarginine-containing protein targets . Molecular Cell . 7 . 5 . 1111–1117 . May 2001 . 11389857 . 10.1016/S1097-2765(01)00244-1 . free .
• Park JW, Voss PG, Grabski S, Wang JL, Patterson RJ . Association of galectin-1 and galectin-3 with Gemin4 in complexes containing the SMN protein . Nucleic Acids Research . 29 . 17 . 3595–3602 . September 2001 . 11522829 . 55878 . 10.1093/nar/29.17.3595 .
• Friesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G, Rappsilber J, Mann M, Dreyfuss G . 6 . The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins . Molecular and Cellular Biology . 21 . 24 . 8289–8300 . December 2001 . 11713266 . 99994 . 10.1128/MCB.21.24.8289-8300.2001 .
• Gubitz AK, Mourelatos Z, Abel L, Rappsilber J, Mann M, Dreyfuss G . Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins . The Journal of Biological Chemistry . 277 . 7 . 5631–5636 . February 2002 . 11714716 . 10.1074/jbc.M109448200 . free .
• Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G . Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component . The Journal of Biological Chemistry . 277 . 9 . 7540–7545 . March 2002 . 11748230 . 10.1074/jbc.M110141200 . free .
• Aerbajinai W, Ishihara T, Arahata K, Tsukahara T . Increased expression level of the splicing variant of SIP1 in motor neuron diseases . The International Journal of Biochemistry & Cell Biology . 34 . 6 . 699–707 . June 2002 . 11943600 . 10.1016/S1357-2725(01)00150-9 .
• Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G . Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex . The Journal of Biological Chemistry . 277 . 35 . 31957–31962 . August 2002 . 12065586 . 10.1074/jbc.M203478200 . free .

Notes and References

1. Fischer U, Liu Q, Dreyfuss G . The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis . Cell . 90 . 6 . 1023–1029 . September 1997 . 9323130 . 10.1016/S0092-8674(00)80368-2 . free .
2. Liu Q, Fischer U, Wang F, Dreyfuss G . The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins . Cell . 90 . 6 . 1013–1021 . September 1997 . 9323129 . 10.1016/S0092-8674(00)80367-0 . free .
3. Web site: Entrez Gene: SIP1 survival of motor neuron protein interacting protein 1.
4. Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G . 6 . miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs . Genes & Development . 16 . 6 . 720–728 . March 2002 . 11914277 . 155365 . 10.1101/gad.974702 . Juri Rappsilber .
5. Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G . Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems . The Journal of Cell Biology . 147 . 6 . 1181–1194 . December 1999 . 10601333 . 2168095 . 10.1083/jcb.147.6.1181 .
6. Meister G, Bühler D, Laggerbauer B, Zobawa M, Lottspeich F, Fischer U . Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins . Human Molecular Genetics . 9 . 13 . 1977–1986 . August 2000 . 10942426 . 10.1093/hmg/9.13.1977 . free .