GSPT1 explained

Eukaryotic peptide chain release factor GTP-binding subunit ERF3A is an enzyme that in humans is encoded by the GSPT1 gene.^{[1] [2] [3]}

Interactions

GSPT1 has been shown to interact with BIRC2.^[4]

Further reading

• Ozawa K, Murakami Y, Eki T, Yokoyama K, Soeda E, Hoshino S, Ui M, Hanaoka F . Mapping of the human GSPT1 gene, a human homolog of the yeast GST1 gene, to chromosomal band 16p13.1 . Somatic Cell and Molecular Genetics . 18 . 2 . 189–94 . Mar 1992 . 1574740 . 10.1007/BF01233164 . 12796634 .
• Kikuchi Y, Shimatake H, Kikuchi A . A yeast gene required for the G1-to-S transition encodes a protein containing an A-kinase target site and GTPase domain . The EMBO Journal . 7 . 4 . 1175–82 . Apr 1988 . 2841115 . 454453 . 10.1002/j.1460-2075.1988.tb02928.x.
• Czaplinski K, Ruiz-Echevarria MJ, Paushkin SV, Han X, Weng Y, Perlick HA, Dietz HC, Ter-Avanesyan MD, Peltz SW . The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs . Genes & Development . 12 . 11 . 1665–77 . Jun 1998 . 9620853 . 316864 . 10.1101/gad.12.11.1665 .
• Hoshino S, Imai M, Mizutani M, Kikuchi Y, Hanaoka F, Ui M, Katada T . Molecular cloning of a novel member of the eukaryotic polypeptide chain-releasing factors (eRF). Its identification as eRF3 interacting with eRF1 . The Journal of Biological Chemistry . 273 . 35 . 22254–9 . Aug 1998 . 9712840 . 10.1074/jbc.273.35.22254 . free .
• Merkulova TI, Frolova LY, Lazar M, Camonis J, Kisselev LL . C-terminal domains of human translation termination factors eRF1 and eRF3 mediate their in vivo interaction . FEBS Letters . 443 . 1 . 41–7 . Jan 1999 . 9928949 . 10.1016/S0014-5793(98)01669-X . 25442225 . free .
• Hoshino S, Imai M, Kobayashi T, Uchida N, Katada T . The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein . The Journal of Biological Chemistry . 274 . 24 . 16677–80 . Jun 1999 . 10358005 . 10.1074/jbc.274.24.16677 . free .
• Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD . Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q . Genomics . 60 . 3 . 295–308 . Sep 1999 . 10493829 . 10.1006/geno.1999.5927 .
• Cosson B, Berkova N, Couturier A, Chabelskaya S, Philippe M, Zhouravleva G . Poly(A)-binding protein and eRF3 are associated in vivo in human and Xenopus cells . Biology of the Cell . 94 . 4–5 . 205–16 . Sep 2002 . 12489690 . 10.1016/S0248-4900(02)01194-2 . 25332754 .
• Hegde R, Srinivasula SM, Datta P, Madesh M, Wassell R, Zhang Z, Cheong N, Nejmeh J, Fernandes-Alnemri T, Hoshino S, Alnemri ES . The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein . The Journal of Biological Chemistry . 278 . 40 . 38699–706 . Oct 2003 . 12865429 . 10.1074/jbc.M303179200 . free .
• Janzen DM, Geballe AP . The effect of eukaryotic release factor depletion on translation termination in human cell lines . Nucleic Acids Research . 32 . 15 . 4491–502 . 2004 . 15326224 . 516063 . 10.1093/nar/gkh791 .
• Le Roy F, Salehzada T, Bisbal C, Dougherty JP, Peltz SW . A newly discovered function for RNase L in regulating translation termination . Nature Structural & Molecular Biology . 12 . 6 . 505–12 . Jun 2005 . 15908960 . 10.1038/nsmb944 . 2576489 .
• Brito M, Malta-Vacas J, Carmona B, Aires C, Costa P, Martins AP, Ramos S, Conde AR, Monteiro C . Polyglycine expansions in eRF3/GSPT1 are associated with gastric cancer susceptibility . Carcinogenesis . 26 . 12 . 2046–9 . Dec 2005 . 15987717 . 10.1093/carcin/bgi168 . free . 10400.21/8620 . free .
• Chauvin C, Salhi S, Le Goff C, Viranaicken W, Diop D, Jean-Jean O . Involvement of human release factors eRF3a and eRF3b in translation termination and regulation of the termination complex formation . Molecular and Cellular Biology . 25 . 14 . 5801–11 . Jul 2005 . 15987998 . 1168810 . 10.1128/MCB.25.14.5801-5811.2005 .
• Kashima I, Yamashita A, Izumi N, Kataoka N, Morishita R, Hoshino S, Ohno M, Dreyfuss G, Ohno S . Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay . Genes & Development . 20 . 3 . 355–67 . Feb 2006 . 16452507 . 1361706 . 10.1101/gad.1389006 .
• Tompkins V, Hagen J, Zediak VP, Quelle DE . Identification of novel ARF binding proteins by two-hybrid screening . Cell Cycle . 5 . 6 . 641–6 . Mar 2006 . 16582619 . 10.4161/cc.5.6.2560 . free .
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . May 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . free .
• Chauvin C, Salhi S, Jean-Jean O . Human eukaryotic release factor 3a depletion causes cell cycle arrest at G1 phase through inhibition of the mTOR pathway . Molecular and Cellular Biology . 27 . 16 . 5619–29 . Aug 2007 . 17562865 . 1952125 . 10.1128/MCB.00035-07 .

Notes and References

1. Hoshino S, Miyazawa H, Enomoto T, Hanaoka F, Kikuchi Y, Kikuchi A, Ui M . A human homologue of the yeast GST1 gene codes for a GTP-binding protein and is expressed in a proliferation-dependent manner in mammalian cells . The EMBO Journal . 8 . 12 . 3807–14 . Dec 1989 . 2511002 . 402068 . 10.1002/j.1460-2075.1989.tb08558.x.
2. Lee JA, Park JE, Lee DH, Park SG, Myung PK, Park BC, Cho S . G1 to S phase transition protein 1 induces apoptosis signal-regulating kinase 1 activation by dissociating 14-3-3 from ASK1 . Oncogene . 27 . 9 . 1297–305 . Feb 2008 . 17700517 . 10.1038/sj.onc.1210740 . free .
3. Web site: Entrez Gene: GSPT1 G1 to S phase transition 1.
4. Hegde R, Srinivasula SM, Datta P, Madesh M, Wassell R, Zhang Z, Cheong N, Nejmeh J, Fernandes-Alnemri T, Hoshino S, Alnemri ES . The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein . The Journal of Biological Chemistry . 278 . 40 . 38699–706 . Oct 2003 . 12865429 . 10.1074/jbc.M303179200 . free .