Monoamine-depleting agent explained

Monoamine-depleting agents are a group of drugs which reversibly deplete one or more of the monoamine neurotransmittersserotonin, dopamine, and norepinephrine.^{[1] [2]} One mechanism by which these agents act is by inhibiting reuptake by the vesicular monoamine transporters, VMAT1 and VMAT2.^[3] Examples of monoamine-depleting agents include deutetrabenazine, oxypertine, reserpine, tetrabenazine, and valbenazine. Tetrabenazine selectively depletes dopamine at low doses and is used as an animal model of amotivation.^{[4] [5]}

See also

• Monoamine neurotoxin
• Monoamine reuptake inhibitor
• Monoamine releasing agent
• Tetrabenazine § Animal model of motivational dysfunction

Notes and References

1. Carlsson A . Monoamine-depleting drugs . Pharmacol Ther B . 1 . 3 . 393–400 . 1975 . 772709 . 10.1016/0306-039x(75)90045-8 .
2. Vijayakumar D, Jankovic J . Drug-Induced Dyskinesia, Part 2: Treatment of Tardive Dyskinesia . Drugs . 76 . 7 . 779–87 . May 2016 . 27091214 . 10.1007/s40265-016-0568-1 . 13570794 .
3. Guay DR . Tetrabenazine, a monoamine-depleting drug used in the treatment of hyperkinetic movement disorders . Am J Geriatr Pharmacother . 8 . 4 . 331–73 . August 2010 . 20869622 . 10.1016/j.amjopharm.2010.08.006 .
4. Callaghan CK, Rouine J, O'Mara SM . Potential roles for opioid receptors in motivation and major depressive disorder . Prog Brain Res . 239 . 89–119 . 2018 . 30314570 . 10.1016/bs.pbr.2018.07.009 .
5. Salamone JD, Correa M, Ferrigno S, Yang JH, Rotolo RA, Presby RE . The Psychopharmacology of Effort-Related Decision Making: Dopamine, Adenosine, and Insights into the Neurochemistry of Motivation . Pharmacol Rev . 70 . 4 . 747–762 . October 2018 . 30209181 . 6169368 . 10.1124/pr.117.015107 .