ZNF350 explained

Zinc finger protein 350 is a protein that in humans is encoded by the ZNF350 gene.^{[1] [2] [3]}

Interactions

ZNF350 has been shown to interact with BRCA1.

See also

• Zinc finger

Further reading

• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Research . 6 . 9 . 791–806 . Sep 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
• Rutter JL, Smith AM, Dávila MR, Sigurdson AJ, Giusti RM, Pineda MA, Doody MM, Tucker MA, Greene MH, Zhang J, Struewing JP . Mutational analysis of the BRCA1-interacting genes ZNF350/ZBRK1 and BRIP1/BACH1 among BRCA1 and BRCA2-negative probands from breast-ovarian cancer families and among early-onset breast cancer cases and reference individuals . Human Mutation . 22 . 2 . 121–8 . Aug 2003 . 12872252 . 10.1002/humu.10238 . 36167584 .
• Yun J, Lee WH . Degradation of transcription repressor ZBRK1 through the ubiquitin-proteasome pathway relieves repression of Gadd45a upon DNA damage . Molecular and Cellular Biology . 23 . 20 . 7305–14 . Oct 2003 . 14517299 . 230312 . 10.1128/MCB.23.20.7305-7314.2003 .
• Tan W, Zheng L, Lee WH, Boyer TG . Functional dissection of transcription factor ZBRK1 reveals zinc fingers with dual roles in DNA-binding and BRCA1-dependent transcriptional repression . The Journal of Biological Chemistry . 279 . 8 . 6576–87 . Feb 2004 . 14660588 . 10.1074/jbc.M312270200 . free .
• Surpili MJ, Delben TM, Kobarg J . Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1 . Biochemistry . 42 . 51 . 15369–76 . Dec 2003 . 14690447 . 10.1021/bi034575v .
• Li H, Seth A . An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein . Oncogene . 23 . 10 . 1801–8 . Mar 2004 . 14755250 . 10.1038/sj.onc.1207319 . 37253372 .
• Tan W, Kim S, Boyer TG . Tetrameric oligomerization mediates transcriptional repression by the BRCA1-dependent Kruppel-associated box-zinc finger protein ZBRK1 . The Journal of Biological Chemistry . 279 . 53 . 55153–60 . Dec 2004 . 15496401 . 10.1074/jbc.M410926200 . free .
• Liao G, Huang J, Fixman ED, Hayward SD . The Epstein-Barr virus replication protein BBLF2/3 provides an origin-tethering function through interaction with the zinc finger DNA binding protein ZBRK1 and the KAP-1 corepressor . Journal of Virology . 79 . 1 . 245–56 . Jan 2005 . 15596820 . 538732 . 10.1128/JVI.79.1.245-256.2005 .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Research . 16 . 1 . 55–65 . Jan 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .
• Bulliard Y, Wiznerowicz M, Barde I, Trono D . KRAB can repress lentivirus proviral transcription independently of integration site . The Journal of Biological Chemistry . 281 . 47 . 35742–6 . Nov 2006 . 16997916 . 10.1074/jbc.M602843200 . free .
• Desjardins S, Belleau P, Labrie Y, Ouellette G, Bessette P, Chiquette J, Laframboise R, Lépine J, Lespérance B, Pichette R, Plante M, Durocher F . Genetic variants and haplotype analyses of the ZBRK1/ZNF350 gene in high-risk non BRCA1/2 French Canadian breast and ovarian cancer families . International Journal of Cancer . 122 . 1 . 108–16 . Jan 2008 . 17764113 . 10.1002/ijc.23058 . 27596530 .

Notes and References

1. Zheng L, Pan H, Li S, Flesken-Nikitin A, Chen PL, Boyer TG, Lee WH . Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1 . Molecular Cell . 6 . 4 . 757–68 . Oct 2000 . 11090615 . 10.1016/S1097-2765(00)00075-7 . free .
2. Ran Q, Wadhwa R, Bischof O, Venable S, Smith JR, Pereira-Smith OM . Characterization of a novel zinc finger gene with increased expression in nondividing normal human cells . Experimental Cell Research . 263 . 1 . 156–62 . Feb 2001 . 11161714 . 10.1006/excr.2000.5068 .
3. Web site: Entrez Gene: ZNF350 zinc finger protein 350.