ZNF300 explained

Zinc finger protein 300 is a protein that in humans is encoded by the ZNF300 gene.^{[1] [2]} The protein encoded by this gene is a C2H2-type zinc finger DNA binding protein and a likely transcription factor.

It is antisense to the human gene, C16orf71, indicating possibility of regulated alternative expression.^[3]

Clinical relevance

It is associated with Crohn's disease.^[4]

References

Further reading

• Feng T, Zhu X . Genome-wide searching of rare genetic variants in WTCCC data . Human Genetics . 128 . 3 . 269–280 . September 2010 . 20549515 . 2922446 . 10.1007/s00439-010-0849-9 .
• Qiu H, Xue L, Gao L, Shao H, Wang D, Guo M, Li W . Identification of the DNA binding element of the human ZNF300 protein . Cellular & Molecular Biology Letters . 13 . 3 . 391–403 . 2008 . 18350257 . 6275660 . 10.2478/s11658-008-0005-x .
• Xu JH, Wang T, Wang XG, Wu XP, Zhao ZZ, Zhu CG, Qiu HL, Xue L, Shao HJ, Guo MX, Li WX . PU.1 can regulate the ZNF300 promoter in APL-derived promyelocytes HL-60 . Leukemia Research . 34 . 12 . 1636–1646 . December 2010 . 20471086 . 10.1016/j.leukres.2010.04.009 .
• Xue L, Qiu H, Ma J, Guo M, Li W . ZNF300, a recently identified human transcription factor, activates the human IL-2Rβ promoter through the overlapping ZNF300/EGR1 binding site . Cellular & Molecular Biology Letters . 15 . 4 . 530–540 . December 2010 . 20585888 . 6275642 . 10.2478/s11658-010-0025-1 .
• Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS . Transcriptome analysis of human gastric cancer . Mammalian Genome . 16 . 12 . 942–954 . December 2005 . 16341674 . 10.1007/s00335-005-0075-2 . 69278 .
• Cao Y, Li JX, Ji CN, Xu XW, Wu M . Molecular cloning and characterization of a novel splice variant of human ZNF300 gene, which expressed highly in testis . DNA Sequence . 18 . 4 . 312–315 . August 2007 . 17541838 . 10.1080/10425170701243393 . 12932222 .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Research . 16 . 1 . 55–65 . January 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .
• Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, Duncanson A, etal . Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls . Nature . 447 . 7145 . 661–678 . June 2007 . 17554300 . 2719288 . 10.1038/nature05911 . Wellcome Trust Case Control Consortium . 2007Natur.447..661B .

Notes and References

1. Gou D, Wang J, Gao L, Sun Y, Peng X, Huang J, Li W . Identification and functional analysis of a novel human KRAB/C2H2 zinc finger gene ZNF300 . Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression . 1676 . 2 . 203–209 . January 2004 . 14746915 . 10.1016/j.bbaexp.2003.11.011 .
2. Web site: Entrez Gene: zinc finger protein 300.
3. Web site: AceView: Gene:C16orf71, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView.. Danielle Thierry-Mieg . Jean Thierry-Mieg . www.ncbi.nlm.nih.gov. 2017-05-20.
4. Prescott NJ, Dominy KM, Kubo M, Lewis CM, Fisher SA, Redon R, Huang N, Stranger BE, Blaszczyk K, Hudspith B, Parkes G, Hosono N, Yamazaki K, Onnie CM, Forbes A, Dermitzakis ET, Nakamura Y, Mansfield JC, Sanderson J, Hurles ME, Roberts RG, Mathew CG . Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease . Human Molecular Genetics . 19 . 9 . 1828–1839 . May 2010 . 20106866 . 2850616 . 10.1093/hmg/ddq041 .