ZMYND11 explained

Zinc finger MYND domain-containing protein 11 is a protein that in humans is encoded by the ZMYND11 gene.^{[1] [2] [3]}

Function

The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified.

Interactions

ZMYND11 has been shown to interact with:

• BMPR1A,^[4]
• C11orf30,^[5]
• ETS2,^[6] and
• TAB1.^[4]
• H3.3K36me3^[7]

Further reading

• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Research . 6 . 9 . 791–806 . Sep 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
• Kurozumi K, Nishita M, Yamaguchi K, Fujita T, Ueno N, Shibuya H . BRAM1, a BMP receptor-associated molecule involved in BMP signalling . Genes to Cells . 3 . 4 . 257–64 . Apr 1998 . 9663660 . 10.1046/j.1365-2443.1998.00186.x . 29818690 .
• Lo KW, Naisbitt S, Fan JS, Sheng M, Zhang M . The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif . The Journal of Biological Chemistry . 276 . 17 . 14059–66 . Apr 2001 . 11148209 . 10.1074/jbc.M010320200 . free .
• Ansieau S, Leutz A . The conserved Mynd domain of BS69 binds cellular and oncoviral proteins through a common PXLXP motif . The Journal of Biological Chemistry . 277 . 7 . 4906–10 . Feb 2002 . 11733528 . 10.1074/jbc.M110078200 . free .
• Wei G, Schaffner AE, Baker KM, Mansky KC, Ostrowski MC . Ets-2 interacts with co-repressor BS69 to repress target gene expression . Anticancer Research . 23 . 3A . 2173–8 . 2003 . 12894593 .
• Hughes-Davies L, Huntsman D, Ruas M, Fuks F, Bye J, Chin SF, Milner J, Brown LA, Hsu F, Gilks B, Nielsen T, Schulzer M, Chia S, Ragaz J, Cahn A, Linger L, Ozdag H, Cattaneo E, Jordanova ES, Schuuring E, Yu DS, Venkitaraman A, Ponder B, Doherty A, Aparicio S, Bentley D, Theillet C, Ponting CP, Caldas C, Kouzarides T . EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer . Cell . 115 . 5 . 523–35 . Nov 2003 . 14651845 . 10.1016/S0092-8674(03)00930-9 . 18911371 . free .
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM . Functional proteomics mapping of a human signaling pathway . Genome Research . 14 . 7 . 1324–32 . Jul 2004 . 15231748 . 442148 . 10.1101/gr.2334104 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Isobe T, Uchida C, Hattori T, Kitagawa K, Oda T, Kitagawa M . Ubiquitin-dependent degradation of adenovirus E1A protein is inhibited by BS69 . Biochemical and Biophysical Research Communications . 339 . 1 . 367–74 . Jan 2006 . 16300738 . 10.1016/j.bbrc.2005.11.028 . 10271/294 . free .
• Wan J, Zhang W, Wu L, Bai T, Zhang M, Lo KW, Chui YL, Cui Y, Tao Q, Yamamoto M, Akira S, Wu Z . BS69, a specific adaptor in the latent membrane protein 1-mediated c-Jun N-terminal kinase pathway . Molecular and Cellular Biology . 26 . 2 . 448–56 . Jan 2006 . 16382137 . 1346911 . 10.1128/MCB.26.2.448-456.2006 .
• Velasco G, Grkovic S, Ansieau S . New insights into BS69 functions . The Journal of Biological Chemistry . 281 . 24 . 16546–50 . Jun 2006 . 16565076 . 10.1074/jbc.M600573200 . free .

Notes and References

1. Hateboer G, Gennissen A, Ramos YF, Kerkhoven RM, Sonntag-Buck V, Stunnenberg HG, Bernards R . BS69, a novel adenovirus E1A-associated protein that inhibits E1A transactivation . The EMBO Journal . 14 . 13 . 3159–69 . Jul 1995 . 7621829 . 394377 . 10.1002/j.1460-2075.1995.tb07318.x.
2. Masselink H, Bernards R . The adenovirus E1A binding protein BS69 is a corepressor of transcription through recruitment of N-CoR . Oncogene . 19 . 12 . 1538–46 . Mar 2000 . 10734313 . 10.1038/sj.onc.1203421 . free .
3. Web site: Entrez Gene: ZMYND11 zinc finger, MYND domain containing 11.
4. Kurozumi K, Nishita M, Yamaguchi K, Fujita T, Ueno N, Shibuya H . BRAM1, a BMP receptor-associated molecule involved in BMP signalling . Genes to Cells . 3 . 4 . 257–64 . Apr 1998 . 9663660 . 10.1046/j.1365-2443.1998.00186.x. 29818690 .
5. Hughes-Davies L, Huntsman D, Ruas M, Fuks F, Bye J, Chin SF, Milner J, Brown LA, Hsu F, Gilks B, Nielsen T, Schulzer M, Chia S, Ragaz J, Cahn A, Linger L, Ozdag H, Cattaneo E, Jordanova ES, Schuuring E, Yu DS, Venkitaraman A, Ponder B, Doherty A, Aparicio S, Bentley D, Theillet C, Ponting CP, Caldas C, Kouzarides T . EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer . Cell . 115 . 5 . 523–35 . Nov 2003 . 14651845 . 10.1016/s0092-8674(03)00930-9. 18911371 . free .
6. Wei G, Schaffner AE, Baker KM, Mansky KC, Ostrowski MC . Ets-2 interacts with co-repressor BS69 to repress target gene expression . Anticancer Research . 23 . 3A . 2173–8 . 12894593 . 2003.
7. 10.1038/nature13045 . 24590075 . 508 . 7495 . ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression . Nature . 263–268. 4142212 . 2014 . Wen . Hong . Li . Yuanyuan . Xi . Yuanxin . Jiang . Shiming . Stratton . Sabrina . Peng . Danni . Tanaka . Kaori . Ren . Yongfeng . Xia . Zheng . Wu . Jun . Li . Bing . Barton . Michelle C. . Li . Wei . Li . Haitao . Shi . Xiaobing .