ZMYM2 explained

Zinc finger MYM-type protein 2 is a protein that in humans is encoded by the ZMYM2 gene.^{[1] [2] [3]}

See also

• Chromosome 13 (human)
• Myeloproliferative neoplasm
• Zinc finger protein

Further reading

• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Research . 6 . 9 . 791–806 . September 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
• Popovici C, Adélaïde J, Ollendorff V, Chaffanet M, Guasch G, Jacrot M, Leroux D, Birnbaum D, Pébusque MJ . Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13) . Proceedings of the National Academy of Sciences of the United States of America . 95 . 10 . 5712–7 . May 1998 . 9576949 . 20444 . 10.1073/pnas.95.10.5712 . free .
• Still IH, Cowell JK . The t(8;13) atypical myeloproliferative disorder: further analysis of the ZNF198 gene and lack of evidence for multiple genes disrupted on chromosome 13 . Blood . 92 . 4 . 1456–8 . August 1998 . 9694738 . 10.1182/blood.V92.4.1456.splL3_1456_1458.
• Reiter A, Sohal J, Kulkarni S, Chase A, Macdonald DH, Aguiar RC, Gonçalves C, Hernandez JM, Jennings BA, Goldman JM, Cross NC . Consistent fusion of ZNF198 to the fibroblast growth factor receptor-1 in the t(8;13)(p11;q12) myeloproliferative syndrome . Blood . 92 . 5 . 1735–42 . September 1998 . 9716603 . 10.1182/blood.V92.5.1735.
• Kulkarni S, Reiter A, Smedley D, Goldman JM, Cross NC . The genomic structure of ZNF198 and location of breakpoints in the t(8;13) myeloproliferative syndrome . Genomics . 55 . 1 . 118–21 . January 1999 . 9889006 . 10.1006/geno.1998.5634 .
• Ollendorff V, Guasch G, Isnardon D, Galindo R, Birnbaum D, Pébusque MJ . Characterization of FIM-FGFR1, the fusion product of the myeloproliferative disorder-associated t(8;13) translocation . The Journal of Biological Chemistry . 274 . 38 . 26922–30 . September 1999 . 10480903 . 10.1074/jbc.274.38.26922 . free .
• Matsumoto K, Morita K, Takada S, Sakura T, Shiozaki H, Murakami H, Miyawaki S . A chronic myelogenous leukemia-like myeloproliferative disorder accompanied by T-cell lymphoblastic lymphoma with chromosome translocation t(8;13)(p11;q12): a Japanese case . International Journal of Hematology . 70 . 4 . 278–82 . December 1999 . 10643154 .
• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination . Genome Research . 10 . 11 . 1788–95 . November 2000 . 11076863 . 310948 . 10.1101/gr.143000 .
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs . Genome Research . 11 . 3 . 422–35 . March 2001 . 11230166 . 311072 . 10.1101/gr.GR1547R .
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S . Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing . EMBO Reports . 1 . 3 . 287–92 . September 2000 . 11256614 . 1083732 . 10.1093/embo-reports/kvd058 .
• Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R . A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes . The Journal of Biological Chemistry . 278 . 9 . 7234–9 . February 2003 . 12493763 . 10.1074/jbc.M208992200 . free.
• Baumann H, Kunapuli P, Tracy E, Cowell JK . The oncogenic fusion protein-tyrosine kinase ZNF198/fibroblast growth factor receptor-1 has signaling function comparable with interleukin-6 cytokine receptors . The Journal of Biological Chemistry . 278 . 18 . 16198–208 . May 2003 . 12594223 . 10.1074/jbc.M300018200 . free .
• Kunapuli P, Somerville R, Still IH, Cowell JK . ZNF198 protein, involved in rearrangement in myeloproliferative disease, forms complexes with the DNA repair-associated HHR6A/6B and RAD18 proteins . Oncogene . 22 . 22 . 3417–23 . May 2003 . 12776193 . 10.1038/sj.onc.1206408 . 21536204 .
• Warner DR, Roberts EA, Greene RM, Pisano MM . Identification of novel Smad binding proteins . Biochemical and Biophysical Research Communications . 312 . 4 . 1185–90 . December 2003 . 14651998 . 10.1016/j.bbrc.2003.11.049 .
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM . Functional proteomics mapping of a human signaling pathway . Genome Research . 14 . 7 . 1324–32 . July 2004 . 15231748 . 442148 . 10.1101/gr.2334104 .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proceedings of the National Academy of Sciences of the United States of America . 101 . 33 . 12130–5 . August 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .

Notes and References

1. Smedley D, Hamoudi R, Clark J, Warren W, Abdul-Rauf M, Somers G, Venter D, Fagan K, Cooper C, Shipley J . The t(8;13)(p11;q11-12) rearrangement associated with an atypical myeloproliferative disorder fuses the fibroblast growth factor receptor 1 gene to a novel gene RAMP . Human Molecular Genetics . 7 . 4 . 637–42 . April 1998 . 9499416 . 10.1093/hmg/7.4.637 . free .
2. Xiao S, Nalabolu SR, Aster JC, Ma J, Abruzzo L, Jaffe ES, Stone R, Weissman SM, Hudson TJ, Fletcher JA . FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome . Nature Genetics . 18 . 1 . 84–7 . January 1998 . 9425908 . 10.1038/ng0198-84 . 826758 .
3. Web site: Entrez Gene: ZMYM2 zinc finger, MYM-type 2.