| State: | WY |
| Type: | WY |
| Route: | 259 |
| Alternate Name: | Horse Ranch Creek Road |
| Map Custom: | yes |
| Map Notes: | WYO 259 highlighted in red |
| Length Mi: | 18.00 |
| Length Round: | 2 |
| Length Ref: | [1] |
| Direction A: | South |
| Direction B: | North |
| Terminus B: | in Midwest |
| Counties: | Natrona |
| Previous Type: | WY |
| Previous Route: | 258 |
| Next Type: | WY |
| Next Route: | 270 |
Wyoming Highway 259 (WYO 259) is an 18adj=midNaNadj=mid north-south state highway located in northeastern Natrona County, north of Casper, in the east-central part of the U.S. state of Wyoming. The highway is the former routing of U.S. Route 87, after that highway was relocated onto Interstate 25.
Wyoming Highway 259 begins its southern end at an interchange with I-25/US 87 (Exit 210).[2] Highway 259 heads north 18miles to the Town of Midwest just east of the Town of Edgerton. Here WYO 259 comes to an end at Wyoming Highway 387 near the Salt Creek Oil Field.[2] Highway 259 is the fastest route for travelers between Casper and Midwest.[3]
Wyoming Highway 259 is the former routing of U.S. Route 87 prior to relocation along Interstate 25.[2]