| State: | WY |
| Type: | WY |
| Route: | 221 |
| Alternate Name: | Fox Farm Road |
| Map: | WY Highway 221 map.svg |
| Length Mi: | 1.84 |
| Length Round: | 2 |
| Length Ref: | [1] |
| Decommissioned: | 2009 |
| Direction A: | West |
| Terminus A: | in Fox Farm-College. |
| Direction B: | East |
| Terminus B: | in Fox Farm-College |
| Counties: | Laramie |
| Previous Type: | WY |
| Previous Route: | 220 |
| Next Type: | WY |
| Next Route: | 222 |
Wyoming Highway 221 was a 1.841NaN1 east - west Wyoming State Road known as Fox Farm Road located in southeastern Cheyenne.
Wyoming Highway 221 traveled from I-25 Business/US 85/US 87 Business (South Greeley Highway) to Wyoming Highway 212 (College Avenue). Highway 221 paralleled Interstate 80 about one-half mile south of the Interstate and served residential and commercial areas.[2] The route was decommissioned in 2009; all state route marker signs have been removed, and the route no longer appears on the Wyoming Official State Highway Map.[2]