| Dr. William O. Walker | |
| Birthname: | William Otis Walker |
| Birth Place: | Selma, Alabama, U.S. |
| Death Place: | Cleveland, Ohio, U.S. |
| Occupation: | publisher of Cleveland Call and Post newspaper,[1] politician, businessman, editor |
| Yearsactive: | 1921–1981 |
| Burial Place: | Lake View Cemetery |
| Education: | Wilberforce University B.A. journalism, Oberlin Business College, M.B. business |
| Party: | Republican |
| Spouse: | |
Dr. William O. Walker aka W.O. Walker (born William Otis Walker on September 19, 1896 – died October 29, 1981) was an African-American publisher, Cleveland-area politician, and editor of the Call and Post, an African-American newspaper based in Cleveland. He was the African-American to serve in an Ohio Governor's cabinet.