| Wassa Amenfi District | |
| Settlement Type: | Former District |
| Pushpin Map: | Ghana |
| Pushpin Map Caption: | Location of Wassa Amenfi District within Western |
| Subdivision Type: | Country |
| Subdivision Name: |  Ghana |
| Subdivision Type1: | Region |
| Subdivision Name1: | Western |
| Subdivision Type2: | Capital |
| Subdivision Name2: | Asankragua |
| Leader Title: | District Executive |
| Timezone: | GMT |
| Utc Offset: | +0 |
| Coordinates: | 5.8092°N -2.4357°W |
| Iso Code: | GH-WP-WA |
Wassa Amenfi District is a former district that was located in Western Region, Ghana. Originally created as an ordinary district assembly in 1988, which was created from the former Aowin-Amenfi District Council. However, in August 2004, it was split off into two new districts: Wassa Amenfi West District (which it was elevated to municipal district assembly status on 15 March 2018; capital: Asankragua) and Wassa Amenfi East District (which it was also elevated to municipal district assembly status on 15 March 2018; capital: Wassa-Akropong). The district assembly was located in the central part of Western Region and had Asankragua as its capital town.