WNT10B explained

Protein Wnt-10b (formerly Wnt12^[1]) is a protein that in humans is encoded by the WNT10B gene.^{[2] [3] [4]}

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis.

This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is, it is presumed, a molecular switch that governs adipogenesis. Gain-of-function of Wnt10b in mouse hearts has shown to improve cardiac tissue repair after myocardial injury, by promoting coronary vessel formation and attenuating pathological fibrosis.^[5] This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region.^[6]

Further reading

• Smolich BD, McMahon JA, McMahon AP, Papkoff J . Wnt family proteins are secreted and associated with the cell surface . Mol. Biol. Cell . 4 . 12 . 1267–75 . 1994 . 8167409 . 10.1091/mbc.4.12.1267. 275763 .
• Bergstein I, Eisenberg LM, Bhalerao J, etal . Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21 . Genomics . 46 . 3 . 450–8 . 1998 . 9441749 . 10.1006/geno.1997.5041 . free .
• Ross SE, Hemati N, Longo KA, etal . Inhibition of adipogenesis by Wnt signaling . Science . 289 . 5481 . 950–3 . 2000 . 10937998 . 10.1126/science.289.5481.950 . 2000Sci...289..950R .
• Kirikoshi H, Sekihara H, Katoh M . WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells . Biochem. Biophys. Res. Commun. . 283 . 4 . 798–805 . 2001 . 11350055 . 10.1006/bbrc.2001.4855 .
• Saitoh T, Kirikoshi H, Mine T, Katoh M . Proto-oncogene WNT10B is up-regulated by tumor necrosis factor alpha in human gastric cancer cell line MKN45 . Int. J. Oncol. . 19 . 6 . 1187–92 . 2002 . 11713588 . 10.3892/ijo.19.6.1187.
• Kasat K, Go V, Pogo BG . Effects of pyrethroid insecticides and estrogen on WNT10B proto-oncogene expression . Environment International . 28 . 5 . 429–32 . 2003 . 12437293 . 10.1016/S0160-4120(02)00072-7 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Christodoulides C, Scarda A, Granzotto M, etal . WNT10B mutations in human obesity . Diabetologia . 49 . 4 . 678–84 . 2006 . 16477437 . 10.1007/s00125-006-0144-4 . 4304000 .
• Thrasivoulou C, Millar M, Ahmed A . Activation of intracellular calcium by multiple Wnt ligands and translocation of β-catenin into the nucleus: a convergent model of Wnt/Ca2+ and Wnt/β-catenin pathways . J. Biol. Chem. . 288 . 50 . 35651–35659 . 2013 . 24158438 . 10.1074/jbc.M112.437913 . 3861617. free .

Notes and References

1. Schubert M, Holland LZ, Holland ND, Jacobs DK . A phylogenetic tree of the Wnt genes based on all available full-length sequences, including five from the cephalochordate amphioxus . Molecular Biology and Evolution . 17 . 12 . 1896–903 . 2000 . 11110906 . 10.1093/oxfordjournals.molbev.a026291. free .
2. Bui TD, Rankin J, Smith K, Huguet EL, Ruben S, Strachan T, Harris AL, Lindsay S . A novel human Wnt gene, WNT10B, maps to 12q13 and is expressed in human breast carcinomas . Oncogene . 14 . 10 . 1249–53 . Apr 1997 . 9121776 . 10.1038/sj.onc.1200936 . free .
3. Hardiman G, Kastelein RA, Bazan JF . Isolation, characterization and chromosomal localization of human WNT10B . Cytogenet Cell Genet . 77 . 3–4 . 278–82 . Sep 1997 . 9284937 . 10.1159/000134597 .
4. Ugur SA, Tolun A . Homozygous WNT10b mutation and complex inheritance in Split-Hand/Foot Malformation . Hum Mol Genet . 17 . 17 . 2644–53 . Aug 2008 . 18515319 . 10.1093/hmg/ddn164 . free .
5. Paik DT, Rai M, Ryzhov S, Sanders LN, Aisagbonhi O, Funke MJ, Feoktistov I, Hatzopoulos AK. Wnt10b gain-of-function improves cardiac repair by arteriole formation and attenuation of fibrosis. Circ Res. 2015; 117:804-816.
6. Web site: Entrez Gene: WNT10B wingless-type MMTV integration site family, member 10B.