WIPI1 explained

WD repeat domain phosphoinositide-interacting protein 1 (WIPI-1), also known as Atg18 protein homolog (ATG18) and WD40 repeat protein interacting with phosphoinositides of 49 kDa (WIPI 49 kDa), is a protein that in humans is encoded by the WIPI1 gene.^{[1] [2] [3]}

Structure and function

WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein–protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI1, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids.^{[1] [3]}

See also

• WIPI protein family

Further reading

• Chasman DI, Paré G, Mora S, Hopewell JC, Peloso G, Clarke R, Cupples LA, Hamsten A, Kathiresan S, Mälarstig A, Ordovas JM, Ripatti S, Parker AN, Miletich JP, Ridker PM . Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis . PLOS Genet. . 5 . 11 . e1000730 . November 2009 . 19936222 . 2777390 . 10.1371/journal.pgen.1000730 . free .
• Behrends C, Sowa ME, Gygi SP, Harper JW . Network organization of the human autophagy system . Nature . 466 . 7302 . 68–76 . July 2010 . 20562859 . 2901998 . 10.1038/nature09204 . 2010Natur.466...68B .
• Proikas-Cezanne T, Ruckerbauer S, Stierhof YD, Berg C, Nordheim A . Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy . FEBS Lett. . 581 . 18 . 3396–404 . July 2007 . 17618624 . 10.1016/j.febslet.2007.06.040 . 23430881 . free .

Notes and References

1. Web site: Entrez Gene: WD repeat domain.
2. Jeffries TR, Dove SK, Michell RH, Parker PJ . PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49 . Mol. Biol. Cell . 15 . 6 . 2652–63 . June 2004 . 15020712 . 420090 . 10.1091/mbc.E03-10-0732 .
3. Proikas-Cezanne T, Waddell S, Gaugel A, Frickey T, Lupas A, Nordheim A . WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy . Oncogene . 23 . 58 . 9314–25 . December 2004 . 15602573 . 10.1038/sj.onc.1208331 . 22642893 .