WDR83 explained
WD repeat domain 83 is a protein that in humans is encoded by the WDR83 gene.[1]
Function
This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway, and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN3, also known as PHD3) and regulates expression of hypoxia-inducible factor 1, and has been purified as part of the spliceosome. Alternative splicing results in multiple transcript variants.
Further reading
- Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ . Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis . RNA . 8 . 4 . 426–39 . 2002 . 11991638 . 1370266 . 10.1017/s1355838202021088.
- Vomastek T, Schaeffer HJ, Tarcsafalvi A, Smolkin ME, Bissonette EA, Weber MJ . Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists . Proc. Natl. Acad. Sci. U.S.A. . 101 . 18 . 6981–6 . 2004 . 15118098 . 406452 . 10.1073/pnas.0305894101 . 2004PNAS..101.6981V . free .
- Hopfer U, Hopfer H, Jablonski K, Stahl RA, Wolf G . The novel WD-repeat protein Morg1 acts as a molecular scaffold for hypoxia-inducible factor prolyl hydroxylase 3 (PHD3) . J. Biol. Chem. . 281 . 13 . 8645–55 . 2006 . 16407229 . 10.1074/jbc.M513751200 . free .
- Haase D, Keiner S, Mawrin C, Wolf G . Reduced Morg1 expression in ischemic human brain . Neurosci. Lett. . 455 . 1 . 46–50 . 2009 . 19429104 . 10.1016/j.neulet.2009.03.048 . 27095825 .
- Su WY, Li JT, Cui Y, Hong J, Du W, Wang YC, Lin YW, Xiong H, Wang JL, Kong X, Gao QY, Wei LP, Fang JY . Bidirectional regulation between WDR83 and its natural antisense transcript DHPS in gastric cancer . Cell Res. . 22 . 9 . 1374–89 . 2012 . 22491477 . 3434345 . 10.1038/cr.2012.57 .
Notes and References
- Web site: Entrez Gene: WD repeat domain 83. 2017-06-15.
