| Varėnė | |
| Mouth Coordinates: | 54.246°N 24.5536°W |
| Subdivision Type1: | Country |
| Subdivision Type2: | Region |
| Length: | 48km (30miles) |
| Discharge1 Avg: | 3.36m3/s |
| Basin Size: | 411km2 |
| Tributaries Left: | Žiegždupis, Žižma, Dusmena, Musė |
| Tributaries Right: | Juodupė, Niedulė, Svetus, Abista |
The Varėnė is a river of Alytus district municipality and Varėna district municipality, Alytus County, southern Lithuania. It flows for 48 kilometres and has a basin area of 411 km².
The Varėnė begins near Skaičionys village. There are a lot of water springs along its upper course. Varėnė crosses the Varėnis Lake near its mouth. It joins the Merkys near Varėna city.
Varėnė suits well for water tourism.