VPREB3 explained

Pre-B lymphocyte protein 3 is a protein that in humans is encoded by the VPREB3 gene.^{[1] [2] [3] [4]}

The VPREB3 gene product is the human homologue of the mouse VpreB3 (8HS20) protein, and is specifically expressed in cell lines representative of all stages of B-lymphocyte differentiation. It is also related to VPREB1 and other members of the immunoglobulin supergene family. The VPREB3 protein apparently associates with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. The precise function of VPREB3 is not known, but it may contribute to mu chain transport in pre-B cells.^[5] In humans, besides the bone marrow and secondary lymphoid tissues such as the tonsils, the VPREB3 protein is also present in Purkinje cells of the cerebellum and in the zona glomerulosa of the adrenal.

Further reading

• Melchers F, Karasuyama H, Haasner D, etal . The surrogate light chain in B-cell development . Immunol. Today . 14 . 2 . 60–8 . 1993 . 8166770 . 10.1016/0167-5699(93)90060-X .
• Ohnishi K, Takemori T . Molecular components and assembly of mu.surrogate light chain complexes in pre-B cell lines . J. Biol. Chem. . 269 . 45 . 28347–53 . 1994 . 10.1016/S0021-9258(18)46934-7 . 7961773 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Clark HF, Gurney AL, Abaya E, etal . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 .
• Collins JE, Wright CL, Edwards CA, etal . A genome annotation-driven approach to cloning the human ORFeome . Genome Biol. . 5 . 10 . R84 . 2005 . 15461802 . 10.1186/gb-2004-5-10-r84 . 545604 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Rangel R, McKeller MR, Sims-Mourtada JC, etal . Assembly of the kappa preB receptor requires a V kappa-like protein encoded by a germline transcript . J. Biol. Chem. . 280 . 18 . 17807–14 . 2005 . 15757909 . 10.1074/jbc.M409479200 . free .

Notes and References

1. Rosnet O, Mattei MG, Delattre O, Schiff C . VPREB3: cDNA characterization and expression in human and chromosome mapping in human and mouse . Cytogenet Cell Genet . 87 . 3–4 . 205–8 . Apr 2000 . 10702669 . 10.1159/000015468 . 5914943 .
2. Felizola SJ, Katsu K, Ise K, Nakamura Y, Arai Y, Satoh F, Sasano H. Pre-B lymphocyte protein 3 (VPREB3) expression in the adrenal cortex: precedent for non-immunological roles in normal and neoplastic human tissues.. Endocrine Pathology . [in press] . 2015 .
3. Rosnet O, Blanco-Betancourt C, Grivel K, Richter K, Schiff C . Binding of free immunoglobulin light chains to VpreB3 inhibits their maturation and secretion in chicken B cells . J Biol Chem . 279 . 11 . 10228–36 . Mar 2004 . 14670953 . 10.1074/jbc.M312169-A200 . free .
4. Web site: Entrez Gene: VPREB3 pre-B lymphocyte gene 3.
5. Web site: Entrez Gene: VPREB3 pre-B lymphocyte gene 3.