VAMP4 explained
Vesicle-associated membrane protein 4 is a protein that in humans is encoded by the VAMP4 gene.[1] [2]
Function
Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport.
Interactions
VAMP4 has been shown to interact with AP1M1,[3] STX6[4] and STX16.[4]
Further reading
- Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA . A "double adaptor" method for improved shotgun library construction . Analytical Biochemistry . 236 . 1 . 107–13 . Apr 1996 . 8619474 . 10.1006/abio.1996.0138 .
- Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA . Large-scale concatenation cDNA sequencing . Genome Research . 7 . 4 . 353–8 . Apr 1997 . 9110174 . 139146 . 10.1101/gr.7.4.353 .
- Steegmaier M, Klumperman J, Foletti DL, Yoo JS, Scheller RH . Vesicle-associated membrane protein 4 is implicated in trans-Golgi network vesicle trafficking . Molecular Biology of the Cell . 10 . 6 . 1957–72 . Jun 1999 . 10359608 . 25394 . 10.1091/mbc.10.6.1957 .
- Scales SJ, Chen YA, Yoo BY, Patel SM, Doung YC, Scheller RH . SNAREs contribute to the specificity of membrane fusion . Neuron . 26 . 2 . 457–64 . May 2000 . 10839363 . 10.1016/S0896-6273(00)81177-0 . free .
- Peden AA, Park GY, Scheller RH . The Di-leucine motif of vesicle-associated membrane protein 4 is required for its localization and AP-1 binding . The Journal of Biological Chemistry . 276 . 52 . 49183–7 . Dec 2001 . 11598115 . 10.1074/jbc.M106646200 . free .
- Mallard F, Tang BL, Galli T, Tenza D, Saint-Pol A, Yue X, Antony C, Hong W, Goud B, Johannes L . Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform . The Journal of Cell Biology . 156 . 4 . 653–64 . Feb 2002 . 11839770 . 2174079 . 10.1083/jcb.200110081 .
- Zeng Q, Tran TT, Tan HX, Hong W . The cytoplasmic domain of Vamp4 and Vamp5 is responsible for their correct subcellular targeting: the N-terminal extenSion of VAMP4 contains a dominant autonomous targeting signal for the trans-Golgi network . The Journal of Biological Chemistry . 278 . 25 . 23046–54 . Jun 2003 . 12682051 . 10.1074/jbc.M303214200 . free .
- Hinners I, Wendler F, Fei H, Thomas L, Thomas G, Tooze SA . AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1 . EMBO Reports . 4 . 12 . 1182–9 . Dec 2003 . 14608369 . 1326413 . 10.1038/sj.embor.7400018 .
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . Nov 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
Notes and References
- Advani RJ, Bae HR, Bock JB, Chao DS, Doung YC, Prekeris R, Yoo JS, Scheller RH . Seven novel mammalian SNARE proteins localize to distinct membrane compartments . The Journal of Biological Chemistry . 273 . 17 . 10317–24 . Apr 1998 . 9553086 . 10.1074/jbc.273.17.10317 . free .
- Web site: Entrez Gene: VAMP4 vesicle-associated membrane protein 4.
- Hinners I, Wendler F, Fei H, Thomas L, Thomas G, Tooze SA . AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1 . EMBO Reports . 4 . 12 . 1182–9 . Dec 2003 . 14608369 . 1326413 . 10.1038/sj.embor.7400018 .
- Mallard F, Tang BL, Galli T, Tenza D, Saint-Pol A, Yue X, Antony C, Hong W, Goud B, Johannes L . Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform . The Journal of Cell Biology . 156 . 4 . 653–64 . Feb 2002 . 11839770 . 2174079 . 10.1083/jcb.200110081 .