V-erbA-related gene explained

V-erbA-related protein 2 (EAR-2) also known as NR2F6 (nuclear receptor subfamily 2 group F member 6) is a protein that in humans is encoded by the NR2F6 gene.^[1] V-erbA-related protein 2 is a member of the nuclear receptor family of intracellular transcription factors. It is named after its similarity to v-erbA, a helper of an oncoprotein called v-erbB in avian erythroblastosis virus.^[2]

Function

Comparatively little is known about ear-2, but it has been shown to function as a coregulator of other nuclear receptors.^{[3] [4]}

Interactions

V-erbA-related gene has been shown to interact with:

• COUP-TFII^[5]
• Thyroid hormone receptor beta

Further reading

• Bähler M, Kehrer I, Gordon L, Stoffler HE, Olsen AS . Physical mapping of human myosin-IXB (MYO9B), the human orthologue of the rat myosin myr 5, to chromosome 19p13.1 . Genomics . 43 . 1 . 107–9 . July 1997 . 9226381 . 10.1006/geno.1997.4776 .
• Avram D, Ishmael JE, Nevrivy DJ, Peterson VJ, Lee SH, Dowell P, Leid M . Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2 . The Journal of Biological Chemistry . 274 . 20 . 14331–6 . May 1999 . 10318855 . 2823254 . 10.1074/jbc.274.20.14331 . free .
• Zhang Y, Dufau ML . Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor . The Journal of Biological Chemistry . 275 . 4 . 2763–70 . January 2000 . 10644740 . 10.1074/jbc.275.4.2763 . free .
• Zhu XG, Park KS, Kaneshige M, Bhat MK, Zhu Q, Mariash CN, McPhie P, Cheng SY . The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear receptor function . Molecular and Cellular Biology . 20 . 7 . 2604–18 . April 2000 . 10713182 . 85476 . 10.1128/MCB.20.7.2604-2618.2000 .
• Liu X, Huang X, Sigmund CD . Identification of a nuclear orphan receptor (Ear2) as a negative regulator of renin gene transcription . Circulation Research . 92 . 9 . 1033–40 . May 2003 . 12690040 . 10.1161/01.RES.0000071355.82009.43 . free .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proceedings of the National Academy of Sciences of the United States of America . 101 . 33 . 12130–5 . August 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .

Notes and References

1. Miyajima N, Kadowaki Y, Fukushige S, Shimizu S, Semba K, Yamanashi Y, Matsubara K, Toyoshima K, Yamamoto T . Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other . Nucleic Acids Research . 16 . 23 . 11057–74 . December 1988 . 2905047 . 338996 . 10.1093/nar/16.23.11057 .
2. Thormeyer D, Baniahmad A . The v-erbA oncogene (review) . International Journal of Molecular Medicine . 4 . 4 . 351–358 . October 1999 . 10493974 .
3. Zhu XG, Park KS, Kaneshige M, Bhat MK, Zhu Q, Mariash CN, McPhie P, Cheng SY . The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear receptor function . Molecular and Cellular Biology . 20 . 7 . 2604–18 . April 2000 . 10713182 . 85476 . 10.1128/MCB.20.7.2604-2618.2000 .
4. Liu X, Huang X, Sigmund CD . Identification of a nuclear orphan receptor (Ear2) as a negative regulator of renin gene transcription . Circulation Research . 92 . 9 . 1033–40 . May 2003 . 12690040 . 10.1161/01.RES.0000071355.82009.43 . free .
5. Avram D, Ishmael JE, Nevrivy DJ, Peterson VJ, Lee SH, Dowell P, Leid M . Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2 . The Journal of Biological Chemistry . 274 . 20 . 14331–6 . May 1999 . 10318855 . 2823254 . 10.1074/jbc.274.20.14331 . free .