| Uspanapa | |
| Name Other: | Uxpanapa, Uzpanapa |
| Map: | Istmo de Tehuantepec hidro.png |
| Subdivision Type1: | Country |
| Subdivision Name1: | Mexico |
| Subdivision Type2: | State |
| Subdivision Name2: | Oaxaca, Veracruz |
| Subdivision Type3: | Region |
| Subdivision Name3: | Isthmus of Tehuantepec |
| Source1 Coordinates: | 17.115°N -94.2831°W |
| Mouth: | Coatzacoalcos River |
| Mouth Coordinates: | 17.9706°N -94.475°W |
The Uspanapa River, also known as the Uxpanapa or Uzpanapa, is a river of Mexico.[1] It originates in the foothills of Sierra Atravesada subrange of the Sierra Madre de Chiapas mountains in the state of Oaxaca. It flows through the Selva Zoque and the municipio of Uxpanapa in the state of Veracruz from which it takes its name. It is a tributary of the Coatzacoalcos River, which it joins downstream from the city of Minatitlán and upstream from Nanchital.