Uroplakin-3a explained

Uroplakin-3a (UP3a) is a protein that in humans is encoded by the UPK3A gene.^{[1] [2]}

UP3a is found in the inner membrane of the urinary bladder and contributes to the strength of that membrane and to the membrane's ability to stretch when the bladder is full.^[3] It is also found in the renal pelvis, ureter, and prostatic urethra.

Further reading

• Wu XR, Sun TT . Molecular cloning of a 47 kDa tissue-specific and differentiation-dependent urothelial cell surface glycoprotein. . J. Cell Sci. . 106 . 1. 31–43 . 1994 . 10.1242/jcs.106.1.31 . 8270634 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Lobban ED, Smith BA, Hall GD, etal . Uroplakin gene expression by normal and neoplastic human urothelium. . Am. J. Pathol. . 153 . 6 . 1957–67 . 1998 . 9846985 . 10.1016/S0002-9440(10)65709-4. 1866332 .
• Ogawa K, Johansson SL, Cohen SM . Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract . Am. J. Pathol. . 155 . 4 . 1047–50 . 1999 . 10514386 . 10.1016/S0002-9440(10)65206-6. 1867018 .
• Olsburgh J, Harnden P, Weeks R, etal . Uroplakin gene expression in normal human tissues and locally advanced bladder cancer . J. Pathol. . 199 . 1 . 41–9 . 2003 . 12474225 . 10.1002/path.1252 . 21523290 .
• Tu L, Sun TT, Kreibich G . Specific heterodimer formation is a prerequisite for uroplakins to exit from the endoplasmic reticulum . Mol. Biol. Cell . 13 . 12 . 4221–30 . 2003 . 12475947 . 10.1091/mbc.E02-04-0211 . 138628 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Koga F, Kawakami S, Fujii Y, etal . Impaired p63 expression associates with poor prognosis and uroplakin III expression in invasive urothelial carcinoma of the bladder . Clin. Cancer Res. . 9 . 15 . 5501–7 . 2004 . 14654529 .
• Collins JE, Wright CL, Edwards CA, etal . A genome annotation-driven approach to cloning the human ORFeome . Genome Biol. . 5 . 10 . R84 . 2005 . 15461802 . 10.1186/gb-2004-5-10-r84 . 545604 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Schönfelder EM, Knüppel T, Tasic V, etal . Mutations in Uroplakin IIIA are a rare cause of renal hypodysplasia in humans . Am. J. Kidney Dis. . 47 . 6 . 1004–12 . 2006 . 16731295 . 10.1053/j.ajkd.2006.02.177 .
• Zeng Y, Wu XX, Homma Y, etal . Uroplakin III-delta4 messenger RNA as a promising marker to identify nonulcerative interstitial cystitis . J. Urol. . 178 . 4 Pt 1 . 1322–7; discussion 1327 . 2007 . 17698128 . 10.1016/j.juro.2007.05.125 .

Notes and References

1. Yuasa T, Yoshiki T, Tanaka T, Kim CJ, Isono T, Okada Y . Expression of uroplakin Ib and uroplakin III genes in tissues and peripheral blood of patients with transitional cell carcinoma . Jpn J Cancer Res . 89 . 9 . 879–82 . Dec 1998 . 9818021 . 5921953 . 10.1111/j.1349-7006.1998.tb00643.x.
2. Web site: Entrez Gene: UPK3A uroplakin 3A.
3. 3717210 . 19340092 . 10.1038/ki.2009.73 . 75 . Uroplakins in urothelial biology, function, and disease . 2009 . Kidney Int. . 1153–65 . Wu XR, Kong XP, Pellicer A, Kreibich G, Sun TT. 11 .