See main article: 1968 United States Senate elections.
| Election Name: | 1968 United States Senate election in Maryland |
| Country: | Maryland |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1962 United States Senate election in Maryland |
| Previous Year: | 1962 |
| Next Election: | 1974 United States Senate election in Maryland |
| Next Year: | 1974 |
| Election Date: | November 5, 1968 |
| Image1: | Charles Mathias.jpg |
| Nominee1: | Charles Mathias |
| Party1: | Republican Party (US) |
| Popular Vote1: | 541,893 |
| Percentage1: | 47.79% |
| Party2: | Democratic Party (US) |
| Popular Vote2: | 443,667 |
| Percentage2: | 39.12% |
| Party3: | American Independent Party |
| Popular Vote3: | 148,467 |
| Percentage3: | 13.09% |
| Map Size: | 275px |
| U.S. Senator | |
| Before Party: | Democratic Party (US) |
| After Party: | Republican Party (US) |
The 1968 United States Senate election in Maryland was held on November 5, 1968. Incumbent Democratic U.S. Senator Daniel Brewster ran for re-election to a second term in office but was defeated by Republican U.S. Representative Charles Mathias. This is the last time a Senator from Maryland lost re-election.
Mathias may have benefited from the campaign of George P. Mahoney, the 1966 Democratic nominee for Governor of Maryland, who ran on the George Wallace American Independent ticket and garnered a significant chunk of the vote.
| Charlies MathiasRepublican | Daniel BrewsterDemocratic | George P. MahoneyAmerican Independent | Margin | TotalVotes Cast | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| % | % | % | % | ||||||||||
| Allegany | 16390 | 52.83% | 10963 | 35.34% | 3672 | 11.84% | 5427 | 17.49% | 31025 | ||||
| Anne Arundel | 34979 | 48.66% | 24719 | 34.39% | 12188 | 16.95% | 10260 | 14.27% | 71886 | ||||
| Baltimore (City) | 86126 | 32.74% | 139890 | 53.18% | 37036 | 14.08% | -53764 | -20.44% | 263052 | ||||
| Baltimore (County) | 106668 | 50.72% | 69966 | 33.27% | 33691 | 16.02% | 36702 | 17.45% | 210325 | ||||
| Calvert | 1844 | 37.19% | 1716 | 34.61% | 1398 | 28.20% | 128 | 2.58% | 4958 | ||||
| Caroline | 2616 | 48.72% | 1769 | 32.95% | 984 | 18.33% | 847 | 15.78% | 5369 | ||||
| Carroll | 10906 | 59.07% | 4694 | 25.42% | 2863 | 15.51% | 6212 | 33.65% | 18463 | ||||
| Cecil | 6466 | 49.23% | 4926 | 37.51% | 1742 | 13.26% | 1540 | 11.73% | 13134 | ||||
| Charles | 3992 | 37.01% | 4161 | 38.58% | 2633 | 24.41% | -169 | -1.57% | 10786 | ||||
| Dorchester | 3486 | 39.79% | 2992 | 34.15% | 2283 | 26.06% | 494 | 5.64% | 8761 | ||||
| Frederick | 17688 | 66.78% | 6863 | 25.91% | 1934 | 7.30% | 10825 | 40.87% | 26485 | ||||
| Garrett | 4086 | 64.57% | 1478 | 23.36% | 764 | 12.07% | 2608 | 41.21% | 6328 | ||||
| Harford | 16046 | 53.55% | 10042 | 33.51% | 3876 | 12.94% | 6004 | 20.04% | 29964 | ||||
| Howard | 9621 | 57.54% | 4661 | 27.88% | 2438 | 14.58% | 4960 | 29.67% | 16720 | ||||
| Kent | 2611 | 46.92% | 2066 | 37.12% | 888 | 15.96% | 545 | 9.79% | 5565 | ||||
| Montgomery | 106466 | 59.34% | 62484 | 34.82% | 10476 | 5.84% | 43982 | 24.51% | 179426 | ||||
| Prince George's | 76073 | 47.93% | 64636 | 40.72% | 18018 | 11.35% | 11437 | 7.21% | 158727 | ||||
| Queen Anne's | 2426 | 45.69% | 1944 | 36.61% | 940 | 17.70% | 482 | 9.08% | 5310 | ||||
| St. Mary's | 2692 | 32.92% | 3393 | 41.49% | 2092 | 25.58% | -701 | -8.57% | 8177 | ||||
| Somerset | 2660 | 45.18% | 1996 | 33.91% | 1231 | 20.91% | 664 | 11.28% | 5887 | ||||
| Talbot | 4368 | 57.44% | 2261 | 29.73% | 976 | 12.83% | 2107 | 27.71% | 7605 | ||||
| Washington | 18714 | 59.11% | 9669 | 30.54% | 3277 | 10.35% | 9045 | 28.57% | 31660 | ||||
| Wicomico | 7698 | 46.09% | 6667 | 39.92% | 2337 | 13.99% | 1031 | 6.17% | 16702 | ||||
| Worcester | 3128 | 52.51% | 1886 | 31.66% | 943 | 15.83% | 1242 | 20.85% | 5957 | ||||
| Total | 547750 | 47.95% | 445842 | 39.03% | 148680 | 13.02% | 101908 | 8.92% | 1142272 | ||||