USP5 explained

Ubiquitin specific peptidase 5 is an enzyme that in humans is encoded by the USP5 gene.^{[1] [2] [3]}

Interactions

USP5 has been shown to interact with TADA3L.^[4]

Further reading

• D'Andrea A, Pellman D . Deubiquitinating enzymes: a new class of biological regulators . Critical Reviews in Biochemistry and Molecular Biology . 33 . 5 . 337–52 . 1999 . 9827704 . 10.1080/10409239891204251 .
• Falquet L, Paquet N, Frutiger S, Hughes GJ, Hoang-Van K, Jaton JC . cDNA cloning of a human 100 kDa de-ubiquitinating enzyme: the 100 kDa human de-ubiquitinase belongs to the ubiquitin C-terminal hydrolase family 2 (UCH2) . FEBS Letters . 376 . 3 . 233–7 . Dec 1995 . 7498549 . 10.1016/0014-5793(95)01287-7 . 19521632 .
• Wilkinson KD, Tashayev VL, O'Connor LB, Larsen CN, Kasperek E, Pickart CM . Metabolism of the polyubiquitin degradation signal: structure, mechanism, and role of isopeptidase T . Biochemistry . 34 . 44 . 14535–46 . Nov 1995 . 7578059 . 10.1021/bi00044a032 .
• Falquet L, Paquet N, Frutiger S, Hughes GJ, Hoang-Van K, Jaton JC . A human de-ubiquitinating enzyme with both isopeptidase and peptidase activities in vitro . FEBS Letters . 359 . 1 . 73–7 . Feb 1995 . 7851534 . 10.1016/0014-5793(94)01451-6 . 39667023 . free .
• Ansari-Lari MA, Shen Y, Muzny DM, Lee W, Gibbs RA . Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination . Genome Research . 7 . 3 . 268–80 . Mar 1997 . 9074930 . 10.1101/gr.7.3.268 . free .
• Suzuki Y, Tsunoda T, Sese J, Taira H, Mizushima-Sugano J, Hata H, Ota T, Isogai T, Tanaka T, Nakamura Y, Suyama A, Sakaki Y, Morishita S, Okubo K, Sugano S . Identification and characterization of the potential promoter regions of 1031 kinds of human genes . Genome Research . 11 . 5 . 677–84 . May 2001 . 11337467 . 311086 . 10.1101/gr.gr-1640r .
• Book: Engidawork E, Juranville JF, Fountoulakis M, Dierssen M, Lubec G . 2001 . Protein Expression in Down Syndrome Brain . Selective upregulation of the ubiquitin-proteasome proteolytic pathway proteins, proteasome zeta chain and isopeptidase T in fetal Down syndrome . Journal of Neural Transmission. Supplementum . 61 . 117–30 . 11771738 . 10.1007/978-3-7091-6262-0_10 . 978-3-211-83704-7 .
• Gabriel JM, Lacombe T, Carobbio S, Paquet N, Bisig R, Cox JA, Jaton JC . Zinc is required for the catalytic activity of the human deubiquitinating isopeptidase T . Biochemistry . 41 . 46 . 13755–66 . Nov 2002 . 12427038 . 10.1021/bi026096m .
• Lacombe T, Gabriel JM . Further characterization of the putative human isopeptidase T catalytic site . FEBS Letters . 531 . 3 . 469–74 . Nov 2002 . 12435595 . 10.1016/S0014-5793(02)03586-X . 26832850 . free .
• Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP, Veenstra TD, Adkins JN, Pounds JG, Fagan R, Lobley A . The human plasma proteome: a nonredundant list developed by combination of four separate sources . Molecular & Cellular Proteomics . 3 . 4 . 311–26 . Apr 2004 . 14718574 . 10.1074/mcp.M300127-MCP200 . free .
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation . Nature Biotechnology . 22 . 6 . 707–16 . Jun 2004 . 15146197 . 10.1038/nbt971 . 27764390 .
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM . Functional proteomics mapping of a human signaling pathway . Genome Research . 14 . 7 . 1324–32 . Jul 2004 . 15231748 . 442148 . 10.1101/gr.2334104 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Reyes-Turcu FE, Horton JR, Mullally JE, Heroux A, Cheng X, Wilkinson KD . The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitin . Cell . 124 . 6 . 1197–208 . Mar 2006 . 16564012 . 10.1016/j.cell.2006.02.038 . 1312137 . free .

Notes and References

1. Puente XS, Sánchez LM, Overall CM, López-Otín C . Human and mouse proteases: a comparative genomic approach . Nature Reviews Genetics . 4 . 7 . 544–58 . Jul 2003 . 12838346 . 10.1038/nrg1111 . 2856065 .
2. Ansari-Lari MA, Muzny DM, Lu J, Lu F, Lilley CE, Spanos S, Malley T, Gibbs RA . A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13 . Genome Research . 6 . 4 . 314–26 . Apr 1996 . 8723724 . 10.1101/gr.6.4.314 . free .
3. Web site: Entrez Gene: USP5 ubiquitin specific peptidase 5 (isopeptidase T).
4. Huda Zoghbi . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .