| State: | OK |
| Type: | US |
| Route: | 75 |
| Map Custom: | yes |
| Map Notes: | US 75 highlighted in red |
| Length Mi: | 249.42 |
| Length Round: | 2 |
| Length Ref: | [1] |
| Direction A: | South |
| Terminus A: | at the Texas state line |
| Junction: | in Durant in Atoka in Calvin in Henryetta in Okmulgee in Tulsa in Tulsa in Tulsa in Bartlesville |
| Direction B: | North |
| Terminus B: | at the Kansas state line |
| Counties: | Bryan, Atoka, Coal, Hughes, Okfuskee, Okmulgee, Tulsa, Washington |
| Previous Type: | OK |
| Previous Route: | 74 |
| Next Type: | OK |
| Next Route: | 76 |
U.S. Route 75 (US 75) is a major north–south highway that enters the U.S. state of Oklahoma from Texas concurrent with US 69 crossing the Red River. US 75 serves the city of Tulsa, the 2nd largest city in Oklahoma.
US 75 enters the state concurrent with US 69 as a freeway. The freeway status drops between Colbert and Calera. The two highways regain their freeway status in Durant. This freeway ends about 12 miles north of Durant. The two highways split in Atoka. Through traffic traveling to Tulsa usually uses US 69 to the Indian Nation Turnpike as a faster route.
Leaving Atoka, US 75 serves many small communities and crosses the Canadian River before reaching I-40/US 62 about 82 miles northwest of Atoka. The three highways travel east to Henryetta. US 62 and US 75 leave I-40 at an interchange with the Indian Nation Turnpike. The two highways serve as a major route through the town. US 62 leaves US 75 in Okmulgee.
Coming out of Okmulgee, US 75 starts to enter a more urban area traveling into Tulsa. US 75 becomes a freeway in Glenpool, interchanging with the Creek Turnpike in Jenks. US 75 travels through western Tulsa before reaching an interchange at I-244. The two highways travel into Downtown Tulsa together, where US 75 splits off with a short overlap with US 64/SH 51. US 75 leaves downtown crossing I-244 for a second time.
US 75 serves north Tulsa before returning to a surface highway. From here, the highway travels to Kansas, only passing through the major community of Bartlesville.
The following is list of names for the expressway part of US 75 in the Tulsa area.