| Tuscumbia River | |
| Source1 Location: | Prentiss County, Mississippi |
| Mouth Location: | Hatchie River |
| Subdivision Type1: | Country |
| Subdivision Name1: | United States |
| Subdivision Type2: | States |
| Subdivision Name2: | Mississippi and Tennessee |
| Length: | 44.4miles |
| Source1 Elevation: | 361feet |
The Tuscumbia River is a 44.4adj=midNaNadj=mid[1] tributary of the Hatchie River in northern Mississippi and western Tennessee in the United States. It rises in Prentiss County, Mississippi, near Booneville. It flows through Alcorn County, then into McNairy County, Tennessee, where it is joined by a major tributary, Cypress Creek, and then flows into the Hatchie River, just before it reaches Hardeman County, near Pocahontas, Tennessee.
Tuscumbia is a name derived from the Chickasaw language purported to mean either "warrior killer" or "warrior rainmaker".[2]