| Topolnița | |
| Pushpin Map: | Romania |
| Subdivision Type1: | Country |
| Subdivision Name1: | Romania |
| Subdivision Type2: | Counties |
| Subdivision Name2: | Mehedinți County |
| Subdivision Type3: | Villages |
| Subdivision Name3: | Mălărișca, Schitu Topolniței, Izvoru Bârzii, Drobeta-Turnu Severin |
| Length: | 44km (27miles) |
| Mouth: | Danube |
| Mouth Location: | Drobeta-Turnu Severin |
| Mouth Coordinates: | 44.6204°N 22.6883°W |
| Basin Size: | 360km2 |
| Tributaries Left: | Balta, Păunești, Neagonea, Pleșuva |
| Tributaries Right: | Clișevăț, Șușița |
The Topolnița is a left tributary of the river Danube in Romania. In the central Mehedinți Plateau it descends into Topolnița Cave, eventually emerging at the foot of a hill downstream.[1] It discharges into the Danube in Drobeta-Turnu Severin.[2] Its length is 44km (27miles) and its basin size is 360km2.