Toker cell explained

A Toker cell is an epithelial cell with clear cytoplasm in the nipple of some women.[1] Toker cells are believed to develop from sebaceous glands.[1] They are cytokeratin 7 (CK7) positive, in contrast to squamous epithelium.[1] Rarely, they can be numerous and atypical, and difficult to distinguish from malignant cells of Paget's disease of the breast.[2] In such cases, immunohistochemistry using CD138 and p53 can be used for distinction, both being negative in Toker cells and positive in Paget's disease.[2]

Notes and References

  1. Saeed. Duaa. Shousha. Sami. Toker cells of the nipple are commonly associated with underlying sebaceous glands but not with lactiferous ducts. Journal of Clinical Pathology. 67. 11. 2014. 1010–1012. 0021-9746. 10.1136/jclinpath-2014-202280. 25086135 . 31216111 .
  2. Di Tommaso. Luca. Franchi. Giada. Destro. Annarita. Broglia. Fabiana. Minuti. Francesco. Rahal. Daoud. Roncalli. Massimo. Toker cells of the breast. Morphological and immunohistochemical characterization of 40 cases. Human Pathology. 39. 9. 2008. 1295–1300. 0046-8177. 10.1016/j.humpath.2008.01.018. 18614197 .

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