Thrombospondin 3 Explained

Thrombospondin-3 (TSP3) is a protein that in humans is encoded by the THBS3 gene.^{[1] [2]}

The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. TSP3 has been found to be involved in the regulation of skeletal maturation.^[3] This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1. Identified as the gene on chromosome 1 responsible for mediating an associated with genetic susceptibility to SARS-CoV-2 infection.^[4]

Further reading

• O'Rourke KM, Laherty CD, Dixit VM . Thrombospondin 1 and thrombospondin 2 are expressed as both homo- and heterotrimers . The Journal of Biological Chemistry . 267 . 35 . 24921–24924 . December 1992 . 1459996 . 10.1016/S0021-9258(19)73983-0 . free .
• Adolph KW, Long GL, Winfield S, Ginns EI, Bornstein P . Structure and organization of the human thrombospondin 3 gene (THBS3) . Genomics . 27 . 2 . 329–336 . May 1995 . 7558000 . 10.1006/geno.1995.1050 .
• Qabar A, Derick L, Lawler J, Dixit V . Thrombospondin 3 is a pentameric molecule held together by interchain disulfide linkage involving two cysteine residues . The Journal of Biological Chemistry . 270 . 21 . 12725–12729 . May 1995 . 7759526 . 10.1074/jbc.270.21.12725 . free .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–174 . January 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Qabar AN, Lin Z, Wolf FW, O'Shea KS, Lawler J, Dixit VM . Thrombospondin 3 is a developmentally regulated heparin binding protein . The Journal of Biological Chemistry . 269 . 2 . 1262–1269 . January 1994 . 8288588 . 10.1016/S0021-9258(17)42252-6 . free .
• Bornstein P, Devarayalu S, Edelhoff S, Disteche CM . Isolation and characterization of the mouse thrombospondin 3 (Thbs3) gene . Genomics . 15 . 3 . 607–613 . March 1993 . 8468055 . 10.1006/geno.1993.1114 .
• Winfield SL, Tayebi N, Martin BM, Ginns EI, Sidransky E . Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease . Genome Research . 7 . 10 . 1020–1026 . October 1997 . 9331372 . 310674 . 10.1101/gr.7.10.1020 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–156 . October 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Adolph KW . Relative abundance of thrombospondin 2 and thrombospondin 3 mRNAs in human tissues . Biochemical and Biophysical Research Communications . 258 . 3 . 792–796 . May 1999 . 10329465 . 10.1006/bbrc.1999.0710 .
• Adolph KW, Bornstein P . The human thrombospondin 3 gene: analysis of transcription initiation and an alternatively spliced transcript . Molecular Cell Biology Research Communications . 2 . 1 . 47–52 . July 1999 . 10527891 . 10.1006/mcbr.1999.0148 .
• Carron JA, Hiscott P, Hagan S, Sheridan CM, Magee R, Gallagher JA . Cultured human retinal pigment epithelial cells differentially express thrombospondin-1, -2, -3, and -4 . The International Journal of Biochemistry & Cell Biology . 32 . 11–12 . 1137–1142 . 2001 . 11137453 . 10.1016/S1357-2725(00)00065-0 .
• Armstrong DJ, Hiscott P, Batterbury M, Kaye S . Corneal stromal cells (keratocytes) express thrombospondins 2 and 3 in wound repair phenotype . The International Journal of Biochemistry & Cell Biology . 34 . 6 . 588–593 . June 2002 . 11943589 . 10.1016/S1357-2725(01)00157-1 .
• Dalla-Torre CA, Yoshimoto M, Lee CH, Joshua AM, de Toledo SR, Petrilli AS, Andrade JA, Chilton-MacNeill S, Zielenska M, Squire JA . Effects of THBS3, SPARC and SPP1 expression on biological behavior and survival in patients with osteosarcoma . BMC Cancer . 6 . 237 . October 2006 . 17022822 . 1609181 . 10.1186/1471-2407-6-237 . free .

Notes and References

1. Vos HL, Devarayalu S, de Vries Y, Bornstein P . Thrombospondin 3 (Thbs3), a new member of the thrombospondin gene family . The Journal of Biological Chemistry . 267 . 17 . 12192–12196 . June 1992 . 1601886 . 10.1016/S0021-9258(19)49823-2 . free .
2. Web site: Entrez Gene: THBS3 thrombospondin 3.
3. Hankenson KD, Hormuzdi SG, Meganck JA, Bornstein P . Mice with a disruption of the thrombospondin 3 gene differ in geometric and biomechanical properties of bone and have accelerated development of the femoral head . Molecular and Cellular Biology . 25 . 13 . 5599–5606 . July 2005 . 15964815 . 1156967 . 10.1128/MCB.25.13.5599-5606.2005 .
4. Niemi ME, Karjalainen J, Liao RG, Neale BM, Daly M, Ganna A, Pathak GA, Andrews SJ, Kanai M, Veerapen K, Fernandez-Cadenas I, Schulte EC, Striano P, Marttila M, Minica C, Marouli E, Karim MA, Wendt FR, Savage J, Sloofman L, Butler-Laporte G, Kim HN, Kanoni S, Okada Y, Byun J, Han Y, Uddin MJ, Smith GD, Willer CJ, Buxbaum JD . Mapping the human genetic architecture of COVID-19 . Nature . 600 . 7889 . 472–477 . December 2021 . 34237774 . 8674144 . 10.1038/s41586-021-03767-x . 2021Natur.600..472C . 235776838 .