Tetrahydroharmol Explained

Drug Name:Tetrahydroharmol
Cas Number:17952-75-9
Unii:DHR7GV467K
Pubchem:368982
Chemspiderid:327573
Chembl:14122
Synonyms:1,2-Dihydroharmaline
Iupac Name:1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-7-ol
C:12
H:14
N:2
O:1
Smiles:CC1C2=C(CCN1)C3=C(N2)C=C(C=C3)O
Stdinchi:1S/C12H14N2O/c1-7-12-10(4-5-13-7)9-3-2-8(15)6-11(9)14-12/h2-3,6-7,13-15H,4-5H2,1H3
Stdinchikey:AZTMWIPCEFFOJD-UHFFFAOYSA-N

Tetrahydroharmol is a bioactive beta-carboline harmala alkaloid.[1] It acts as a reversible inhibitor of monoamine oxidase A.[2]

Legal Status

Australia

Harmala alkaloids are considered Schedule 9 prohibited substances under the Poisons Standard (October 2015).[3] A Schedule 9 substance is a substance which may be abused or misused, the manufacture, possession, sale or use of which should be prohibited by law except when required for medical or scientific research, or for analytical, teaching or training purposes with approval of Commonwealth and/or State or Territory Health Authorities.

See also

Notes and References

  1. Riba J, McIlhenny EH, Valle M, Bouso JC, Barker SA . Metabolism and disposition of N,N-dimethyltryptamine and harmala alkaloids after oral administration of ayahuasca . Drug Testing and Analysis . 4 . 7–8 . 610–616 . 2012 . 22514127 . 10.1002/dta.1344 .
  2. Buckholtz NS, Boggan WO . Monoamine oxidase inhibition in brain and liver produced by beta-carbolines: structure-activity relationships and substrate specificity . Biochemical Pharmacology . 26 . 21 . 1991–1996 . November 1977 . 921812 . 10.1016/0006-2952(77)90007-7 . Elsevier BV .
  3. Web site: Poisons Standard October 2015 . September 2015 . Australian Government Department of Health .

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