TSPAN3 explained

Tetraspanin-3 is a protein that in humans is encoded by the TSPAN3 gene.^[1]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains.

The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. Two alternative transcripts encoding different isoforms have been described.

Further reading

• Berditchevski F . Complexes of tetraspanins with integrins: more than meets the eye. . J. Cell Sci. . 114 . Pt 23 . 4143–51 . 2002 . 10.1242/jcs.114.23.4143 . 11739647 .
• Otsuki T, Ota T, Nishikawa T, etal . Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. . DNA Res. . 12 . 2 . 117–26 . 2007 . 16303743 . 10.1093/dnares/12.2.117 . free .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Todd SC, Doctor VS, Levy S . Sequences and expression of six new members of the tetraspanin/TM4SF family. . Biochim. Biophys. Acta . 1399 . 1 . 101–4 . 1998 . 9714763 . 10.1016/s0167-4781(98)00087-6. free .
• Wu YJ, Noguchi CT . Activation of globin gene expression by cDNAs from induced K562 cells. Evidence for involvement of ferritin in globin gene expression. . J. Biol. Chem. . 266 . 26 . 17566–72 . 1991 . 10.1016/S0021-9258(19)47409-7 . 1840594 . free .

Notes and References

1. Web site: Entrez Gene: TSPAN3 tetraspanin 3.