TRIM55 explained

Tripartite motif-containing protein 55 is a protein that in humans is encoded by the TRIM55 gene.^{[1] [2]}

The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein associates transiently with microtubules, myosin, and titin during muscle sarcomere assembly. It may act as a transient adaptor and plays a regulatory role in the assembly of sarcomeres. Four alternatively spliced transcript variants encoding distinct isoforms have been described.

Further reading

• McElhinny AS, Kakinuma K, Sorimachi H, etal . Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1 . J. Cell Biol. . 157 . 1 . 125–36 . 2002 . 11927605 . 10.1083/jcb.200108089 . 2173255 .
• Pizon V, Iakovenko A, Van Der Ven PF, etal . Transient association of titin and myosin with microtubules in nascent myofibrils directed by the MURF2 RING-finger protein . J. Cell Sci. . 115 . Pt 23 . 4469–82 . 2003 . 12414993 . 10.1242/jcs.00131 . 16068484 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Kim J, Bhinge AA, Morgan XC, Iyer VR . Mapping DNA-protein interactions in large genomes by sequence tag analysis of genomic enrichment . Nat. Methods . 2 . 1 . 47–53 . 2005 . 15782160 . 10.1038/nmeth726 . 6135437 .
• Lange S, Xiang F, Yakovenko A, etal . The kinase domain of titin controls muscle gene expression and protein turnover . Science . 308 . 5728 . 1599–603 . 2005 . 15802564 . 10.1126/science.1110463 . 10.1.1.383.9888 . 2809403 .
• Witt SH, Granzier H, Witt CC, Labeit S . MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination . J. Mol. Biol. . 350 . 4 . 713–22 . 2005 . 15967462 . 10.1016/j.jmb.2005.05.021 .

Notes and References

1. Centner T, Yano J, Kimura E, McElhinny AS, Pelin K, Witt CC, Bang ML, Trombitas K, Granzier H, Gregorio CC, Sorimachi H, Labeit S . Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain . J Mol Biol . 306 . 4 . 717–26 . Mar 2001 . 11243782 . 10.1006/jmbi.2001.4448 .
2. Web site: Entrez Gene: TRIM55 tripartite motif-containing 55.