TCF7L1 explained

Transcription factor 7-like 1, also known as TCF7L1, is a human gene.^[1]

This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence.^[1]

Further reading

• Castrop J, van Norren K, Clevers H . A gene family of HMG-box transcription factors with homology to TCF-1 . Nucleic Acids Research . 20 . 3 . 611 . Feb 1992 . 1741298 . 310434 . 10.1093/nar/20.3.611 .
• Sagara N, Katoh M . Mitomycin C resistance induced by TCF-3 overexpression in gastric cancer cell line MKN28 is associated with DT-diaphorase down-regulation . Cancer Research . 60 . 21 . 5959–62 . Nov 2000 . 11085512 .
• Kim TW, Kim HJ, Lee C, Kim HY, Baek SH, Kim JH, Kwon KS, Kim JR . Identification of replicative senescence-associated genes in human umbilical vein endothelial cells by an annealing control primer system . Experimental Gerontology . 43 . 4 . 286–95 . Apr 2008 . 18258400 . 10.1016/j.exger.2007.12.010 . 37034259 .
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR . Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score . Molecular Medicine . 2010 . 16 . 7–8 . 247–53 . 20379614 . 2896464 . 10.2119/molmed.2009.00159 .
• Katoh M . Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis . Stem Cell Reviews . 3 . 1 . 30–8 . Jan 2007 . 17873379 . 10.1007/s12015-007-0006-6 . 20861838 .
• Filleur S, Hirsch J, Wille A, Schön M, Sell C, Shearer MH, Nelius T, Wieland I . INTS6/DICE1 inhibits growth of human androgen-independent prostate cancer cells by altering the cell cycle profile and Wnt signaling . Cancer Cell International . 9 . 28 . 2009 . 19906297 . 2779787 . 10.1186/1475-2867-9-28 . free .
• Balaz P, Plaschke J, Krüger S, Görgens H, Schackert HK . TCF-3, 4 protein expression correlates with beta-catenin expression in MSS and MSI-H colorectal cancer from HNPCC patients but not in sporadic colorectal cancers . International Journal of Colorectal Disease . 25 . 8 . 931–9 . Aug 2010 . 20532534 . 10.1007/s00384-010-0959-9 . 22778766 .
• Salins P, Shawesh S, He Y, Dibrov A, Kashour T, Arthur G, Amara F . Lovastatin protects human neurons against Abeta-induced toxicity and causes activation of beta-catenin-TCF/LEF signaling . Neuroscience Letters . 412 . 3 . 211–6 . Feb 2007 . 17234346 . 10.1016/j.neulet.2006.07.045 . 53251386 .
• Halatsch ME, Löw S, Mursch K, Hielscher T, Schmidt U, Unterberg A, Vougioukas VI, Feuerhake F . Candidate genes for sensitivity and resistance of human glioblastoma multiforme cell lines to erlotinib. Laboratory investigation . Journal of Neurosurgery . 111 . 2 . 211–8 . Aug 2009 . 19301967 . 10.3171/2008.9.JNS08551 .
• Barker N, Huls G, Korinek V, Clevers H . Restricted high level expression of Tcf-4 protein in intestinal and mammary gland epithelium . The American Journal of Pathology . 154 . 1 . 29–35 . Jan 1999 . 9916915 . 1853446 . 10.1016/S0002-9440(10)65247-9 .
• Velasco J, Zarrabeitia MT, Prieto JR, Perez-Castrillon JL, Perez-Aguilar MD, Perez-Nuñez MI, Sañudo C, Hernandez-Elena J, Calvo I, Ortiz F, Gonzalez-Macias J, Riancho JA . Wnt pathway genes in osteoporosis and osteoarthritis: differential expression and genetic association study . Osteoporosis International . 21 . 1 . 109–18 . Jan 2010 . 19373426 . 10.1007/s00198-009-0931-0 . 8813712 .
• Graham TA, Weaver C, Mao F, Kimelman D, Xu W . Crystal structure of a beta-catenin/Tcf complex . Cell . 103 . 6 . 885–96 . Dec 2000 . 11136974 . 10.1016/S0092-8674(00)00192-6 . 16865193 . free .
• Lukas J, Mazna P, Valenta T, Doubravska L, Pospichalova V, Vojtechova M, Fafilek B, Ivanek R, Plachy J, Novak J, Korinek V . Dazap2 modulates transcription driven by the Wnt effector TCF-4 . Nucleic Acids Research . 37 . 9 . 3007–20 . May 2009 . 19304756 . 2685103 . 10.1093/nar/gkp179 .
• Ollila HM, Soronen P, Silander K, Palo OM, Kieseppä T, Kaunisto MA, Lönnqvist J, Peltonen L, Partonen T, Paunio T . Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort . Molecular Psychiatry . 14 . 4 . 351–3 . Apr 2009 . 19308021 . 2694406 . 10.1038/mp.2008.122 .
• Pollheimer J, Loregger T, Sonderegger S, Saleh L, Bauer S, Bilban M, Czerwenka K, Husslein P, Knöfler M . Activation of the canonical wingless/T-cell factor signaling pathway promotes invasive differentiation of human trophoblast . The American Journal of Pathology . 168 . 4 . 1134–47 . Apr 2006 . 16565489 . 1606554 . 10.2353/ajpath.2006.050686 .
• Brantjes H, Roose J, van De Wetering M, Clevers H . All Tcf HMG box transcription factors interact with Groucho-related co-repressors . Nucleic Acids Research . 29 . 7 . 1410–9 . Apr 2001 . 11266540 . 31284 . 10.1093/nar/29.7.1410 .

Notes and References

1. Web site: TCF7L1 transcription factor 7 like 1 [Homo sapiens (human) ]]. 2021-05-29.