TBPO explained
TBPO is an extremely toxic bicyclic phosphate convulsant and GABA receptor antagonist. It is the most toxic bicyclic phosphate known, with an of 36 μg/kg in mice.[1]
Some sources claim that TBPO is as toxic as VX.[2]
Synthesis
The synthesis is equivalent to the synthesis of IPTBO while the triol is produced by the condensation between 3,3-dimethylbutyraldehyde and formaldehyde analogous to the synthesis of trimethylolpropane.
See also
Notes and References
- Milbrath . Dean S. . Engel . Judith L. . Verkade . John G. . Casida . John E. . Structure-toxicity relationships of 1-substituted-4-alkyl-2,6,7-trioxabicyclo[2.2.2.]octanes . Toxicology and Applied Pharmacology . February 1979 . 47 . 2 . 287–293 . 10.1016/0041-008x(79)90323-5 . 452023. 1979ToxAP..47..287M .
- Book: Gupta, Ramesh Chandra . Handbook of toxicology of chemical warfare agents. vanc . Elsevier/Academic Press. 2015. 9780128004944. 2nd. Amsterdam. 228–229. 433545336.
