TBPL1 explained

TATA box-binding protein-like protein 1 is a protein that in humans is encoded by the TBPL1 gene.^{[1] [2] [3] [4]}

Function

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that serves the same function as TBP and substitutes for TBP at some promoters that are not recognized by TFIID. It is essential for spermiogenesis and believed to be important in expression of developmentally regulated genes.^[4]

Interactions

TBPL1 has been shown to interact with GTF2A1.^{[5] [6]}

Further reading

• Ohbayashi T, Makino Y, Tamura TA . Identification of a mouse TBP-like protein (TLP) distantly related to the drosophila TBP-related factor . Nucleic Acids Research . 27 . 3 . 750–5 . Feb 1999 . 9889269 . 148243 . 10.1093/nar/27.3.750 .
• Teichmann M, Wang Z, Martinez E, Tjernberg A, Zhang D, Vollmer F, Chait BT, Roeder RG . Human TATA-binding protein-related factor-2 (hTRF2) stably associates with hTFIIA in HeLa cells . Proceedings of the National Academy of Sciences of the United States of America . 96 . 24 . 13720–5 . Nov 1999 . 10570139 . 24131 . 10.1073/pnas.96.24.13720 . 1999PNAS...9613720T . free .
• Martianov I, Brancorsini S, Gansmuller A, Parvinen M, Davidson I, Sassone-Corsi P . Distinct functions of TBP and TLF/TRF2 during spermatogenesis: requirement of TLF for heterochromatic chromocenter formation in haploid round spermatids . Development . 129 . 4 . 945–55 . Feb 2002 . 10.1242/dev.129.4.945 . 11861477 . free .
• Kieffer-Kwon P, Martianov I, Davidson I . Cell-specific nucleolar localization of TBP-related factor 2 . Molecular Biology of the Cell . 15 . 10 . 4356–68 . Oct 2004 . 15269281 . 519132 . 10.1091/mbc.E04-02-0138 .
• Huda Zoghbi . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .

Notes and References

1. Ohbayashi T, Kishimoto T, Makino Y, Shimada M, Nakadai T, Aoki T, Kawata T, Niwa S, Tamura T . Isolation of cDNA, chromosome mapping, and expression of the human TBP-like protein . Biochemical and Biophysical Research Communications . 255 . 1 . 137–42 . Feb 1999 . 10082669 . 10.1006/bbrc.1999.0159 .
2. Rabenstein MD, Zhou S, Lis JT, Tjian R . TATA box-binding protein (TBP)-related factor 2 (TRF2), a third member of the TBP family . Proceedings of the National Academy of Sciences of the United States of America . 96 . 9 . 4791–6 . Apr 1999 . 10220372 . 21770 . 10.1073/pnas.96.9.4791 . 1999PNAS...96.4791R . free .
3. Chong JA, Moran MM, Teichmann M, Kaczmarek JS, Roeder R, Clapham DE . TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP . Molecular and Cellular Biology . 25 . 7 . 2632–43 . Apr 2005 . 15767669 . 1061635 . 10.1128/MCB.25.7.2632-2643.2005 .
4. Web site: Entrez Gene: TBPL1 TBP-like 1.
5. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .
6. Teichmann M, Wang Z, Martinez E, Tjernberg A, Zhang D, Vollmer F, Chait BT, Roeder RG . Human TATA-binding protein-related factor-2 (hTRF2) stably associates with hTFIIA in HeLa cells . Proceedings of the National Academy of Sciences of the United States of America . 96 . 24 . 13720–5 . Nov 1999 . 10570139 . 24131 . 10.1073/pnas.96.24.13720 . 1999PNAS...9613720T . free .