TAX1BP3 explained

Tax1-binding protein 3 is a protein that in humans is encoded by the TAX1BP3 gene.^[1] ^[2] ^[3] This name is in reference to the Tax1 protein of the Human T-cell Lymphotropic Virus (HTLV) which was used to discover Tax1BP3 in a yeast 2-hybrid screen and subsequently verified by co-IP. TIP1, as it is also known, is a PDZ domain containing protein. However, unlike most PDZ domain proteins which act as scaffolds and often contain multiple PDZ domains as well as other protein domains, TIP1 is essentially just the PDZ domain. This has led to the speculation that TIP1 acts as an inhibitor, either acting to separate PDZ binding motifs from their normal targets or simply preventing the protein to migrate away from the cytosol.

Further reading

Banerjee M, etal . Specificity and promiscuity in human glutaminase interacting protein recognition: insight from the binding of the internal and C-terminal motif. . Biochemistry . 51 . 35 . 6950–6960 . 2012 . 22876914 . 10.1021/bi3008033 . 3433589.
Rousset R, Fabre S, Desbois C, etal . The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins. . Oncogene . 16 . 5 . 643–654 . 1998 . 9482110 . 10.1038/sj.onc.1201567 . free .
Reynaud C, Fabre S, Jalinot P . The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element. . J. Biol. Chem. . 275 . 43 . 33962–33968 . 2000 . 10940294 . 10.1074/jbc.M000465200 . free .
Olalla L, Aledo JC, Bannenberg G, Márquez J . The C-terminus of human glutaminase L mediates association with PDZ domain-containing proteins. . FEBS Lett. . 488 . 3 . 116–122 . 2001 . 11163757 . 10.1016/S0014-5793(00)02373-5 . 11614189 .
Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
Kanamori M, Sandy P, Marzinotto S, etal . The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells. . J. Biol. Chem. . 278 . 40 . 38758–38764 . 2003 . 12874278 . 10.1074/jbc.M306324200 . free .
Twizere JC, Kruys V, Lefèbvre L, etal . Interaction of retroviral Tax oncoproteins with tristetraprolin and regulation of tumor necrosis factor-alpha expression. . J. Natl. Cancer Inst. . 95 . 24 . 1846–1859 . 2004 . 14679154 . 10.1093/jnci/djg118. free .
Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–45 . 2004 . 14702039 . 10.1038/ng1285 . free .
Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–2127 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
Hampson L, Li C, Oliver AW, etal . The PDZ protein Tip-1 is a gain of function target of the HPV16 E6 oncoprotein. . Int. J. Oncol. . 25 . 5 . 1249–1256 . 2005 . 15492812 . 10.3892/ijo.25.5.1249.
Alewine C, Olsen O, Wade JB, Welling PA . TIP-1 has PDZ scaffold antagonist activity. . Mol. Biol. Cell . 17 . 10 . 4200–4211 . 2007 . 16855024 . 10.1091/mbc.E06-02-0129 . 1635354 .

Notes and References

Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA . A "double adaptor" method for improved shotgun library construction . Anal Biochem . 236 . 1 . 107–113 . Jun 1996 . 8619474 . 10.1006/abio.1996.0138 .
Touchman JW, Anikster Y, Dietrich NL, Maduro VV, McDowell G, Shotelersuk V, Bouffard GG, Beckstrom-Sternberg SM, Gahl WA, Green ED . The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion . Genome Res . 10 . 2 . 165–173 . Mar 2000 . 10673275 . 310836 . 10.1101/gr.10.2.165 .
Web site: Entrez Gene: TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3.