TARS (gene) explained

Threonyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the TARS gene.^[1]

Aminoacyl tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase family^[2]

See also

• Aminoacyl tRNA synthetase

Further reading

• Freist W, Gauss DH . Threonyl-tRNA synthetase. . Biol. Chem. Hoppe-Seyler . 376 . 4 . 213–24 . 1995 . 7626230 .
• Cruzen ME, Arfin SM . Nucleotide and deduced amino acid sequence of human threonyl-tRNA synthetase reveals extensive homology to the Escherichia coli and yeast enzymes. . J. Biol. Chem. . 266 . 15 . 9919–23 . 1991 . 10.1016/S0021-9258(18)92906-6 . 2033077 . free .
• Kontis KJ, Arfin SM . Isolation of a cDNA clone for human threonyl-tRNA synthetase: amplification of the structural gene in borrelidin-resistant cell lines. . Mol. Cell. Biol. . 9 . 5 . 1832–8 . 1989 . 2747635 . 10.1128/MCB.9.5.1832. 362973 .
• Gerken SC, Wasmuth JJ, Arfin SM . Threonyl-tRNA synthetase gene maps close to leucyl-tRNA synthetase gene on human chromosome 5. . Somat. Cell Mol. Genet. . 12 . 5 . 519–22 . 1986 . 3464105 . 10.1007/BF01539923 . 32380159 .
• Pan F, Lee HH, Pai SH, Lo KY . Purification and subunit structure studies of human placental threonyl-tRNA synthetase. . Int. J. Pept. Protein Res. . 19 . 3 . 300–9 . 1982 . 7118399 . 10.1111/j.1399-3011.1982.tb03042.x .
• Pan F, Lo KY, Pai SH, Lee HH . Kinetic mechanism of threonyl-tRNA synthetase from human placenta. . Int. J. Pept. Protein Res. . 20 . 2 . 159–66 . 1982 . 7118437 . 10.1111/j.1399-3011.1982.tb02670.x .
• Ogata K, Kurahashi A, Nishiyama C, Terao K . Presence of role of the 5SrRNA-L5 protein complex (5SRNP) in the threonyl- and histidyl-tRNA synthetase complex in rat liver cytosol. . Biochim. Biophys. Acta . 1218 . 3 . 388–400 . 1994 . 8049265 . 10.1016/0167-4781(94)90192-9.
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Vasilescu J, Zweitzig DR, Denis NJ, etal . The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells . J. Proteome Res. . 6 . 1 . 298–305 . 2007 . 17203973 . 10.1021/pr060438j . 10.1.1.401.4220 .
• Tu LC, Yan X, Hood L, Lin B . Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells . Mol. Cell. Proteomics . 6 . 4 . 575–88 . 2007 . 17220478 . 10.1074/mcp.M600249-MCP200 . free .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .

Notes and References

1. Web site: Entrez Gene: TARS threonyl-tRNA synthetase.
2. Web site: Entrez Gene: TARS threonyl-tRNA synthetase.