| Honorific-Prefix: | Hon. |
| Sumedha Jayasena | |
| Honorific-Suffix: | MP |
| Office: | Minister of Women's Affairs |
| Term Start: | 19 October 2000 |
| Term End: | 19 November 2005 |
| Office2: | Minister of Women Affairs & Social Welfare |
| Term Start2: | 23 November 2005 |
| Term End2: | 23 April 2010 |
| Office3: | Minister of Parliamentary Affairs |
| Term Start3: | 23 April 2010 |
| Term End3: | 12 January 2015 |
| Office4: | Deputy Minister of Sustainable Development and Wildlife |
| Term Start4: | 9 September 2015 |
| Term End4: | 2 May 2018 |
| Constituency Mp5: | Monaragala District |
| Parliament5: | Sri Lanka |
| Term Start5: | 12 November 1994 |
| Term End5: | 12 August 2020 |
| Birth Date: | 29 July 1952 |
| Nationality: | Sri Lankan |
| Party: | Sri Lanka Freedom Party |
| Otherparty: | United People's Freedom Alliance |
| Residence: | No. 114, Wellawaya Road, Monaragala |
Sumedha Gunawathie Jayasena (සුමේධා ගුණවතී ජයසේන) is a Sri Lankan politician who has served as a member of the Parliament of Sri Lanka and as a government cabinet minister. After the tragic murder of her husband, Jayasena De Silva, she was elected to take his place in Parliament.
Throughout her career, Sumedha G. Jayasena has held various cabinet ministerial positions and has been dedicated to serving her constituency of Monaragala. She played a role in the post-tsunami rehabilitation and rebuilding efforts in 2004 as the Minister of Social Services.