Suliana Manley Explained

Suliana Manley
Nationality:American
Website:https://leb.epfl.ch
Alma Mater:Rice University
Workplaces:École Polytechnique Fédérale de Lausanne (EPFL)
Main Interests:Super-resolution fluorescence microscopy
Single molecule imaging in cells
Cellular biophysics
Bacterial cell cycle

Suliana Manley (born 1975) is an American biophysicist. Her research focuses on the development of high-resolution optical instruments, and their application in studying the organization and dynamics of proteins. She is a professor at École Polytechnique Fédérale de Lausanne and heads the Laboratory of Experimental Biophysics.[1] [2] [3]

Career

Manley studied physics and mathematics at Rice University where she received a Bachelor's degree (cum laude) in 1997. She joined Harvard University and in 2004 graduated with a PhD in physics under the supervision of Dave A. Weitz.[4] [5] She then went to work as a postdoctoral researcher on lipid bilayer and red blood cell membrane dynamics with Alice P. Gast at MIT.[6] In 2006, she joined the cell biology laboratory of Jennifer Lippincott-Schwartz at the National Institutes of Health as post-doctoral fellow. Here she developed an optical method (sptPALM) enabling the study of the dynamics of large ensembles of single proteins in membranes and inside cells.[7] [8]

In 2009, she became an assistant professor of physics at the École Polytechnique Fédérale de Lausanne, and was promoted to associate professor in 2016 and to full professor in 2022. She is the founding director of the Laboratory of Experimental Biophysics.

Recognition

In 2019, Manley was awarded the Medal for Innovation in Light Microscopy by Royal Microscopical Society.[9] In 2020, she was elected as an APS (American Physical Society) fellow.[10]

Research

Manley's research group is invested in the field of high-resolution optical instruments and in the investigation of complex biological systems. They develop and deploy automated super-resolution fluorescence imaging techniques combined with live cell imaging and single molecule tracking. Their aim is to determine both the dynamics and the spatial distribution of protein assembly. They are also interested in the information transduction across cell membranes and therefore investigate the assembly dynamics of membrane-bound receptor.[11] [12] [13]

Their main research topics involve:

Publication

References

  1. Web site: 21 professors appointed at ETH Zurich and EPFL ETH-Board. 2020-09-17. www.ethrat.ch.
  2. Web site: Prof. Suliana Manley. 2020-09-17. www.epfl.ch. en-GB.
  3. Testa . Andrea . 2022-09-26 . Professor Suliana Manley promoted to Full Professor . en.
  4. Cipelletti. Luca. Manley. S.. Ball. R. C.. Weitz. D. A.. 2000-03-06. Universal Aging Features in the Restructuring of Fractal Colloidal Gels. Physical Review Letters. 84. 10. 2275–2278. 10.1103/PhysRevLett.84.2275. 11017262. 2000PhRvL..84.2275C.
  5. Cipelletti. Luca. Ramos. Laurence. Manley. S.. Pitard. E.. Weitz. D. A.. Pashkovski. Eugene E.. Johansson. Marie. 2003-01-13. Universal non-diffusive slow dynamics in aging soft matter. Faraday Discussions. 123. 237–251. 10.1039/b204495a. 12638864. 2003FaDi..123..237C .
  6. Web site: The Gast Group. 2020-09-17. web.mit.edu.
  7. Patterson. George. Davidson. Michael. Manley. Suliana. Lippincott-Schwartz. Jennifer. 2010-05-05. Superresolution Imaging using Single-Molecule Localization. Annual Review of Physical Chemistry. en. 61. 1. 345–367. 10.1146/annurev.physchem.012809.103444. 0066-426X. 3658623. 20055680.
  8. Shtengel. G.. Galbraith. J. A.. Galbraith. C. G.. Lippincott-Schwartz. J.. Gillette. J. M.. Manley. S.. Sougrat. R.. Waterman. C. M.. Kanchanawong. P.. Davidson. M. W.. Fetter. R. D.. 2009-03-03. Interferometric fluorescent super-resolution microscopy resolves 3D cellular ultrastructure. Proceedings of the National Academy of Sciences. en. 106. 9. 3125–3130. 10.1073/pnas.0813131106. 0027-8424. 2637278. 19202073. 2009PNAS..106.3125S. free.
  9. Web site: Mel. Medal Series. 2020-09-17. www.rms.org.uk.
  10. Web site: APS Fellow Archive. 2020-10-16. www.aps.org. en.
  11. Web site: Research. 2020-09-18. www.epfl.ch. en-GB.
  12. Web site: jake.saltzman@photonics.com. JAKE SALTZMAN, NEWS EDITOR. Improved Illumination Design of Superresolution Microscope Technology. 2020-09-18. www.photonics.com.
  13. Web site: Getting a bigger picture with superresolution microscopy. 2020-09-18. Chemical & Engineering News. en.
  14. Douglass. Kyle M.. Sieben. Christian. Archetti. Anna. Lambert. Ambroise. Manley. Suliana. 2016-10-16. Super-resolution imaging of multiple cells by optimized flat-field epi-illumination. Nature Photonics. en. 10. 11. 705–708. 10.1038/nphoton.2016.200. 1749-4885. 5089541. 27818707. 2016NaPho..10..705D.
  15. Manley. Suliana. Gillette. Jennifer M. Patterson. George H. Shroff. Hari. Hess. Harald F. Betzig. Eric. Lippincott-Schwartz. Jennifer. 2008-01-13. High-density mapping of single-molecule trajectories with photoactivated localization microscopy. Nature Methods. en. 5. 2. 155–157. 10.1038/nmeth.1176. 18193054. 1101468. 1548-7091.
  16. Lukinavičius. Gražvydas. Umezawa. Keitaro. Olivier. Nicolas. Honigmann. Alf. Yang. Guoying. Plass. Tilman. Mueller. Veronika. Reymond. Luc. Corrêa Jr. Ivan R.. Luo. Zhen-Ge. Schultz. Carsten. 2013-01-06. A near-infrared fluorophore for live-cell super-resolution microscopy of cellular proteins. Nature Chemistry. en. 5. 2. 132–139. 10.1038/nchem.1546. 23344448. 2013NatCh...5..132L. 1755-4330. 11858/00-001M-0000-000E-BB40-E. free.
  17. Sage. Daniel. Kirshner. Hagai. Pengo. Thomas. Stuurman. Nico. Min. Junhong. Manley. Suliana. Unser. Michael. 2015-06-15. Quantitative evaluation of software packages for single-molecule localization microscopy. Nature Methods. en. 12. 8. 717–724. 10.1038/nmeth.3442. 26076424. 11781779. 1548-7091.
  18. Archetti. Anna. Glushkov. Evgenii. Sieben. Christian. Stroganov. Anton. Aleksandra Radenovic. Radenovic. Aleksandra. Manley. Suliana. 2019-03-19. Waveguide-PAINT offers an open platform for large field-of-view super-resolution imaging. Nature Communications. en. 10. 1. 1267. 10.1038/s41467-019-09247-1. 2041-1723. 6427008. 30894525. 2019NatCo..10.1267A.
  19. Goujon. Antoine. Colom. Adai. Straková. Karolína. Mercier. Vincent. Mahecic. Dora. Manley. Suliana. Sakai. Naomi. Roux. Aurélien. Matile. Stefan. 2019-02-27. Mechanosensitive Fluorescent Probes to Image Membrane Tension in Mitochondria, Endoplasmic Reticulum, and Lysosomes. Journal of the American Chemical Society. en. 141. 8. 3380–3384. 10.1021/jacs.8b13189. 30744381. 73419245 . 0002-7863.
  20. Kleele . Tatjana . Rey . Timo . Winter . Julius . Zaganelli . Sofia . Mahecic . Dora . Perreten Lambert . Hélène . Ruberto . Francesco Paolo . Nemir . Mohamed . Wai . Timothy . Pedrazzini . Thierry . Manley . Suliana . May 2021 . Distinct fission signatures predict mitochondrial degradation or biogenesis . Nature . en . 593 . 7859 . 435–439 . 10.1038/s41586-021-03510-6 . 33953403 . 2021Natur.593..435K . 233867754 . 1476-4687.

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