Stephen D. M. Brown Explained

Steve Brown
Birth Name:Stephen David Macleod Brown
Birth Date:1955 5, df=yes
Birth Place:Dumfries, Scotland
Education:Belfast Royal Academy
Alma Mater:University of Cambridge (BA, PhD)
Thesis Title:The molecular organisation and evolution of rodent genomes
Thesis Url:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252843
Thesis Year:1981
Doctoral Advisor:Gabriel Dover[1] [2]
Doctoral Students:Elizabeth Fisher[3]

Steve David Macleod Brown (born 3 May 1955) is a British geneticist who is director of the Medical Research Council (MRC) Mammalian Genetics Unit, MRC Harwell at Harwell Science and Innovation Campus, Oxfordshire,[4] [5] [6] [7] a research centre on mouse genetics. In addition, he leads the Genetics and Pathobiology of Deafness research group.[8]

Education

Brown was educated at Belfast Royal Academy and St Catharine's College, Cambridge, where he was awarded a Bachelor of Arts degree in 1977 followed by a PhD in 1981 for research on the molecular organisation and evolution of rodent genomes[9] supervised by Gabriel Dover.

Career and research

Brown conducts research in mouse genetics and genomics. He has studied repeated sequences in the DNA of mice and produced molecular maps of mouse chromosomes, which were used to sequence the mouse genome.[10] [11] He subsequently pioneered efforts to functionally annotate the mouse genome and identify and generate novel disease models through mutagenesis and phenotyping. In particular, he has identified key proteins involved in hearing, contributing to the understanding of the genetics of deafness. For example, research in Brown's laboratory has shown that a mutation in the Evi1 gene increases susceptibility to inflammation of the middle ear (otitis media) in mice, leading to hearing loss.[12]

A particular focus has been the use of mouse models to elucidate the molecular basis of genetic deafness. With Karen Steel, he discovered myosin VIIA as the gene underlying the shaker-1 mutant – one of the first deafness genes to be identified.

Prior to being appointed director of Harwell in 1998, Brown was a professor at Imperial College London.[13] He is chair of the International Mouse Phenotyping Consortium steering committee and joint editor-in-chief of the journal Mammalian Genome.[14] [15]

Awards and honours

Brown was awarded The Genetics Society Medal in 2009, elected a Fellow of the Academy of Medical Sciences in 2001, and elected a Fellow of the Royal Society (FRS) in 2015.[16] [17] His certificate of election reads:

Notes and References

  1. 7146894 . 1982 . Dover . G. A. . Molecular drive . Science . 218 . 4577 . 1069 . Strachan . T . Coen . E. S. . Brown . S. D. . 10.1126/science.7146895. 1982Sci...218.1069D .
  2. 6276556 . 1981 . Brown . S. D. . Organization and evolutionary progress of a dispersed repetitive family of sequences in widely separated rodent genomes . Journal of Molecular Biology . 150 . 4 . 441–66 . Dover . G . 10.1016/0022-2836(81)90374-0.
  3. PhD. University of London. 10044/1/66999. Microcloning and molecular mapping of the mouse X chromosome. Elizabeth Mary Claire. Fisher. 1987. . london.ac.uk. 1103939662.
  4. 9435276. 1998. Silver. L. M.. Mammalian Genome, Incorporating Mouse Genome. Mammalian Genome. 9. 1. 1. Nadeau. J. H.. Brown. S. D. M.. Eppig. J. T.. Peters. J . 10.1007/s003359900669. 42368624.
  5. 22940749. 3774932. 2012. Brown. S. D.. The International Mouse Phenotyping Consortium: Past and future perspectives on mouse phenotyping. Mammalian Genome. 23. 9–10. 632–40. Moore. M. W.. 10.1007/s00335-012-9427-x.
  6. Brown. S. D. M.. Moore. M. W.. Towards an encyclopaedia of mammalian gene function: the International Mouse Phenotyping Consortium. Disease Models & Mechanisms. 5. 3. 2012. 289–292. 1754-8403. 10.1242/dmm.009878. 22566555. 3339821.
  7. Web site: https://web.archive.org/web/20150604091354/http://www.insight.mrc.ac.uk/2012/05/23/profile-steve-brown/ . 2015-06-04 . Profile: Steve Brown . Medical Research Council.
  8. Web site: Genetics and Pathobiology of Deafness research group . MRC Harwell . Harwell.
  9. PhD . University of Cambridge . The molecular organisation and evolution of rodent genomes . cam.ac.uk. Stephen D. M. . Brown . 1981 . . 556404448.
  10. Brown. S. D. M.. Dover. G. A.. Conservation of segmental variants of satellite DNA of Mus musculus in a related species: Mus spretus. Nature. 285. 5759. 1980. 47–49. 0028-0836. 10.1038/285047a0. 7374752. 1980Natur.285...47B. 4326610.
  11. 6276556. 1981. Brown . S. D. . Stephen D. M. Brown. Organization and evolutionary progress of a dispersed repetitive family of sequences in widely separated rodent genomes. Journal of Molecular Biology. 150. 4. 441–66. Dover . G . Gabriel Dover . 10.1016/0022-2836(81)90374-0.
  12. 17029558 . 1592239 . 2006 . Parkinson . N . Mutation at the Evi1 locus in Junbo mice causes susceptibility to otitis media . PLOS Genetics . 2 . 10 . e149 . Hardisty-Hughes . R. E. . Tateossian . H . Tsai . H. T. . Brooker . D . Morse . S . Lalane . Z . MacKenzie . F . Fray . M . Glenister . P . Woodward . A. M. . Polley . S . Barbaric . I . Dear . N . Hough . T. A. . Hunter . A. J. . Cheeseman . M. T. . Brown . S. D. . 10.1371/journal.pgen.0020149 . free .
  13. Web site: https://web.archive.org/web/20140924221214/http://www.har.mrc.ac.uk/about/mrc-harwell-timeline . MRC Harwell Timeline. 2014-09-24 . Medical Research Council .
  14. Web site: Mammalian Genome: Editorial Board . 2015-08-14. Springer .
  15. Web site: IMPC Steering Committee . International Mouse Phenotyping Consortium.
  16. Web site: Professor Stephen Brown FMedSci FRS . Royal Society. Anon. 2015 . 2015-05-02 . https://web.archive.org/web/20150502130930/https://royalsociety.org/people/fellowship/2015/stephen-brown/ . London.
  17. Web site: Professor Steve Brown FMedSci FRS . https://web.archive.org/web/20151117101000/https://royalsociety.org/people/steve-brown-11152/ . 2015-11-17 . . London . Anon. 2015. One or more of the preceding sentences incorporates text from the royalsociety.org website where:

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