Sphinganine C4-monooxygenase explained

Sphinganine C4-monooxygenase (sphingolipid C4-hydroxylase, SUR2 (gene), SBH1 (gene), SBH2 (gene)) is an enzyme with systematic name sphinganine,NADPH:oxygen oxidoreductase (C4-hydroxylating).^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

sphinganine + NADPH + H⁺ + O₂

phytosphingosine + NADP⁺ + H₂O

Sphinganine C4-monooxygenase is involved in the biosynthesis of sphingolipids in yeast and plants.

Notes and References

1. Haak D, Gable K, Beeler T, Dunn T . Hydroxylation of Saccharomyces cerevisiae ceramides requires Sur2p and Scs7p . The Journal of Biological Chemistry . 272 . 47 . 29704–10 . November 1997 . 9368039 . 10.1074/jbc.272.47.29704 . free .
2. Grilley MM, Stock SD, Dickson RC, Lester RL, Takemoto JY . Syringomycin action gene SYR2 is essential for sphingolipid 4-hydroxylation in Saccharomyces cerevisiae . The Journal of Biological Chemistry . 273 . 18 . 11062–8 . May 1998 . 9556590 . 10.1074/jbc.273.18.11062 . free .
3. Sperling P, Ternes P, Moll H, Franke S, Zähringer U, Heinz E . Functional characterization of sphingolipid C4-hydroxylase genes from Arabidopsis thaliana . FEBS Letters . 494 . 1–2 . 90–4 . April 2001 . 11297741 . 10.1016/s0014-5793(01)02332-8 . free .