| State: | SC |
| Type: | SC |
| Route: | 742 |
| Map: | SC 742 map.svg |
| Length Mi: | 3.510 |
| Length Ref: | [1] |
| Established: | 1942 |
| Direction A: | South |
| Terminus A: | near Chesterfield |
| Direction B: | North |
| Terminus B: | at the North Carolina state line |
| Counties: | Chesterfield |
| Previous Type: | SC |
| Previous Route: | 707 |
| Next Type: | SC |
| Next Route: | 760 |
South Carolina Highway 742 (SC 742) is a 3.51miles primary state highway in the U.S. state of South Carolina. It connects Chesterfield with Wadesboro, North Carolina.
SC 742 is a two-lane rural highway that traverses from SC 145, near Chesterfield, to the North Carolina state line. The road continues into North Carolina as North Carolina Highway 742 (NC 742) towards Wadesboro.
It was established in 1942 as a renumbering of SC 850 and to match NC 742, little has changed since. SC 850 was established in 1940 as a new primary routing from SC 85 to the North Carolina state line.