| State: | SC |
| Type: | SC |
| Route: | 375 |
| Map Custom: | yes |
| Length Mi: | 9.330 |
| Length Round: | 3 |
| Length Ref: | [1] |
| Established: | 1949 |
| Direction A: | South |
| Terminus A: | near Lane |
| Junction: | near Lane |
| Direction B: | North |
| Terminus B: | in Greeleyville |
| Counties: | Williamsburg |
| Previous Type: | SC |
| Previous Route: | 363 |
| Next Type: | SC |
| Next Route: | 377 |
South Carolina Highway 375 (SC 375) is a 9.33adj=midNaNadj=mid state highway in the U.S. state of South Carolina. The highway connects rural areas of Williamsburg County with Greeleyville.
SC 375 begins at an intersection with the southern terminus of SC 377 (Martin Luther King Jr. Avenue) south-southwest of Lane, Williamsburg County, where the roadway continues as Santee Road. It travels to the northwest and immediately crosses some railroad tracks. Then, it intersects U.S. Route 52 (US 52; South Williamsburg County Highway). It curves to the north-northwest and passes Mt. Hope Cemetery. Then, the highway enters Greeleyville, where it passes Greeleyville Elementary School. It then meets its northern terminus, an intersection with US 521 (Society Street).