| Honorific-Prefix: | Honourable |
| Sophia Simba | |
| Honorific-Suffix: | MP |
| Office: | Minister of Community Development, Gender and Children |
| Term Start: | 28 November 2010 |
| Term End: | 5 November 2015 |
| President: | Jakaya Kikwete |
| Term Start2: | 6 January 2006 |
| Term End2: | 13 February 2008 |
| President2: | Jakaya Kikwete |
| Office3: | Minister of State in the President's Office for Good Governance |
| Term Start3: | 13 February 2008 |
| Term End3: | 28 November 2010 |
| President3: | Jakaya Kikwete |
| Office4: | Member of Parliament |
| Term Start4: | December 2005 |
| Constituency4: | None (Special Seat) |
| Birth Date: | 27 July 1950 |
| Birth Place: | Tanganyika |
| Nationality: | Tanzanian |
| Party: | CCM |
Sophia Mattayo Simba (born 27 July 1950) is a Tanzanian CCM politician and a special seat Member of Parliament since 2010. She was the Minister of Community Development, Gender and Children.[1]